FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001293975> ?p ?o ?g. }

• W2001293975 endingPage "67" @default.
• W2001293975 startingPage "59" @default.
• W2001293975 abstract "A series of novel N(4)-substituted 4-(2-aminoethyl)benzenesulfonamides 5-17 have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), that is the cytosolic CA I and II, and tumor-associated isozymes CA IX and XII. Against the human CA I investigated compounds displayed KI values from 96.3 to 3520 nM, toward hCA II at range of 18.1-2055 nM, while against hCA IX ranging from 5.9 to 419 nM and against hCA XII in the range of 4.0-414 nM. The very good inhibitory activity against tumor-associated hCA IX and hCA XII was found. The six new compounds displayed a powerful inhibitory potency toward hCA IX (K(I) = 5.9-10.7 nM) in comparison with the clinically used CAIs AAZ, MZA, EZA, DCP and IND (24-50 nM). The most potent hCA IX and hCA XII inhibitors 11 and 12 (K(I): 5.9 and 6.2 nM for hCA IX and 4.3 and 4.0 nM for hCA XII, respectively) belonged to the compounds with cationic character and presented meaningful affinity to the transmembrane isoforms hCA IX and XII than to physiologically dominant isozymes hCA I and II with the selectivity ratios hCA IX versus hCA II and hCA XII versus hCA II for 11 and 12 in the range of 10-15." @default.
• W2001293975 created "2016-06-24" @default.
• W2001293975 creator A5022864557 @default.
• W2001293975 creator A5029225656 @default.
• W2001293975 creator A5035013697 @default.
• W2001293975 creator A5042800841 @default.
• W2001293975 creator A5060631228 @default.
• W2001293975 creator A5075527892 @default.
• W2001293975 creator A5035868230 @default.
• W2001293975 date "2014-09-01" @default.
• W2001293975 modified "2023-09-27" @default.
• W2001293975 title "Synthesis of a new series of N4-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII" @default.
• W2001293975 cites W1549224984 @default.
• W2001293975 cites W1573899446 @default.
• W2001293975 cites W1971852295 @default.
• W2001293975 cites W1974087287 @default.
• W2001293975 cites W1976582886 @default.
• W2001293975 cites W1985377830 @default.
• W2001293975 cites W1993105964 @default.
• W2001293975 cites W1995011648 @default.
• W2001293975 cites W2007695861 @default.
• W2001293975 cites W2022203610 @default.
• W2001293975 cites W2030627791 @default.
• W2001293975 cites W2044044962 @default.
• W2001293975 cites W2045271160 @default.
• W2001293975 cites W2047178318 @default.
• W2001293975 cites W2051349300 @default.
• W2001293975 cites W2073662758 @default.
• W2001293975 cites W2084788967 @default.
• W2001293975 cites W2098685167 @default.
• W2001293975 cites W2101908524 @default.
• W2001293975 cites W2104030311 @default.
• W2001293975 cites W2106141197 @default.
• W2001293975 cites W2116184358 @default.
• W2001293975 cites W2137482466 @default.
• W2001293975 cites W2155704998 @default.
• W2001293975 cites W2155870973 @default.
• W2001293975 cites W2313063363 @default.
• W2001293975 cites W4254431641 @default.
• W2001293975 cites W4376849759 @default.
• W2001293975 cites W4211118618 @default.
• W2001293975 doi "https://doi.org/10.1016/j.ejmech.2014.06.074" @default.
• W2001293975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25016228" @default.
• W2001293975 hasPublicationYear "2014" @default.
• W2001293975 type Work @default.
• W2001293975 sameAs 2001293975 @default.
• W2001293975 citedByCount "18" @default.
• W2001293975 countsByYear W20012939752015 @default.
• W2001293975 countsByYear W20012939752016 @default.
• W2001293975 countsByYear W20012939752017 @default.
• W2001293975 countsByYear W20012939752018 @default.
• W2001293975 countsByYear W20012939752019 @default.
• W2001293975 countsByYear W20012939752020 @default.
• W2001293975 countsByYear W20012939752022 @default.
• W2001293975 countsByYear W20012939752023 @default.
• W2001293975 crossrefType "journal-article" @default.
• W2001293975 hasAuthorship W2001293975A5022864557 @default.
• W2001293975 hasAuthorship W2001293975A5029225656 @default.
• W2001293975 hasAuthorship W2001293975A5035013697 @default.
• W2001293975 hasAuthorship W2001293975A5035868230 @default.
• W2001293975 hasAuthorship W2001293975A5042800841 @default.
• W2001293975 hasAuthorship W2001293975A5060631228 @default.
• W2001293975 hasAuthorship W2001293975A5075527892 @default.
• W2001293975 hasConcept C104317684 @default.
• W2001293975 hasConcept C118792377 @default.
• W2001293975 hasConcept C119795356 @default.
• W2001293975 hasConcept C161790260 @default.
• W2001293975 hasConcept C170493617 @default.
• W2001293975 hasConcept C178790620 @default.
• W2001293975 hasConcept C181199279 @default.
• W2001293975 hasConcept C183882617 @default.
• W2001293975 hasConcept C185592680 @default.
• W2001293975 hasConcept C24530287 @default.
• W2001293975 hasConcept C2775914622 @default.
• W2001293975 hasConcept C53345823 @default.
• W2001293975 hasConcept C55493867 @default.
• W2001293975 hasConcept C71240020 @default.
• W2001293975 hasConcept C98539663 @default.
• W2001293975 hasConceptScore W2001293975C104317684 @default.
• W2001293975 hasConceptScore W2001293975C118792377 @default.
• W2001293975 hasConceptScore W2001293975C119795356 @default.
• W2001293975 hasConceptScore W2001293975C161790260 @default.
• W2001293975 hasConceptScore W2001293975C170493617 @default.
• W2001293975 hasConceptScore W2001293975C178790620 @default.
• W2001293975 hasConceptScore W2001293975C181199279 @default.
• W2001293975 hasConceptScore W2001293975C183882617 @default.
• W2001293975 hasConceptScore W2001293975C185592680 @default.
• W2001293975 hasConceptScore W2001293975C24530287 @default.
• W2001293975 hasConceptScore W2001293975C2775914622 @default.
• W2001293975 hasConceptScore W2001293975C53345823 @default.
• W2001293975 hasConceptScore W2001293975C55493867 @default.
• W2001293975 hasConceptScore W2001293975C71240020 @default.
• W2001293975 hasConceptScore W2001293975C98539663 @default.
• W2001293975 hasLocation W20012939751 @default.
• W2001293975 hasLocation W20012939752 @default.
• W2001293975 hasOpenAccess W2001293975 @default.
• W2001293975 hasPrimaryLocation W20012939751 @default.
• W2001293975 hasRelatedWork W1971852295 @default.

• next