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• W2001298788 abstract "We have examined the effects of chronic thyroid hormone deficiency, vitamin A deficiency, and subsequent acute repletion with thyroid hormone (T 3 ) and/or retinoic acid (RA) on the expression of hepatic apolipoprotein (apo) A-I mRNA. Chronically hypothyroid and/or retinoid-deficient male Lewis rats were treated once or three times with T 3 , all- trans -RA, or both hormones. The hypothyroid state significantly reduced ( P < 0.001) and the vitamin A-deficient state significantly elevated ( P < 0.0001) the expression of apo A-I mRNA. A single injection of T 3 (10 μg/100 gm body weight) significantly elevated apo A-I mRNA in hypothyroid rats ( P < 0.001). A single injection of RA (20 μg/rat) reduced apo A-I mRNA by about 20 to 25% and daily injection of RA for three days reduced apo A-I mRNA abundance further in hypothyroid ( P < 0.05), but not euthyroid, rats. There was a significant interaction between T 3 hormone treatment and vitamin A status of the rats, as well as between RA and T 3 treatment and the thyroid status of the rats. These in vivo results may indicate that nuclear retinoid receptors and thyroid hormone receptors interact in the regulation of the apo A-I gene in liver." @default.
• W2001298788 created "2016-06-24" @default.
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• W2001298788 date "1997-08-01" @default.
• W2001298788 modified "2023-09-25" @default.
• W2001298788 title "Vitamin A deficiency increases hepatic apolipoprotein A-I mRNA expression in both euthyroid and hypothyroid rats" @default.
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• W2001298788 doi "https://doi.org/10.1016/s0955-2863(97)00055-7" @default.
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