FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001331132> ?p ?o ?g. }

• W2001331132 endingPage "1991" @default.
• W2001331132 startingPage "1986" @default.
• W2001331132 abstract "CD8(+) T-cell responses are central for the resolution of hepatitis C virus (HCV) infection, and viral escape from these CD8(+) T-cell responses has been suggested to play a major role in HCV persistence. However, the factors determining the emergence of CD8 escape mutations are not well understood. Here, the first identification of four HLA-A26-restricted CD8(+) T-cell epitopes is reported. Of note, two of these four epitopes are located in the NS3/4A and NS5A/5B cleavage sites. The latter epitope is targeted in all (three of three) patients with acute, resolving HCV infection and in a relatively high proportion (four of 14) of patients with chronic HCV infection. Importantly, the epitope corresponding to the NS5A/5B cleavage site is characterized by the complete absence of sequence variations, despite the presence of functional virus-specific CD8(+) T cells in our cohort. These results support previous findings that showed defined functional constraints within this region. They also suggest that the absence of viral escape may be determined by viral fitness cost and highlight an attractive target for immunotherapies." @default.
• W2001331132 created "2016-06-24" @default.
• W2001331132 creator A5033665234 @default.
• W2001331132 creator A5037546703 @default.
• W2001331132 creator A5041720192 @default.
• W2001331132 creator A5053120770 @default.
• W2001331132 creator A5054558829 @default.
• W2001331132 creator A5054826514 @default.
• W2001331132 creator A5054943079 @default.
• W2001331132 date "2007-07-01" @default.
• W2001331132 modified "2023-09-26" @default.
• W2001331132 title "Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site" @default.
• W2001331132 cites W1511803520 @default.
• W2001331132 cites W1528432054 @default.
• W2001331132 cites W1574175588 @default.
• W2001331132 cites W1965776393 @default.
• W2001331132 cites W1969057879 @default.
• W2001331132 cites W1980215946 @default.
• W2001331132 cites W1981136135 @default.
• W2001331132 cites W1982868643 @default.
• W2001331132 cites W1985680307 @default.
• W2001331132 cites W2004151652 @default.
• W2001331132 cites W2042167668 @default.
• W2001331132 cites W2046178003 @default.
• W2001331132 cites W2085256975 @default.
• W2001331132 cites W2098062401 @default.
• W2001331132 cites W2102428015 @default.
• W2001331132 cites W2103802132 @default.
• W2001331132 cites W2106927931 @default.
• W2001331132 cites W2111359040 @default.
• W2001331132 cites W2149270925 @default.
• W2001331132 cites W2152786092 @default.
• W2001331132 cites W2159853150 @default.
• W2001331132 cites W2161945006 @default.
• W2001331132 cites W2168287637 @default.
• W2001331132 cites W2170946314 @default.
• W2001331132 cites W2171540341 @default.
• W2001331132 cites W4250217270 @default.
• W2001331132 doi "https://doi.org/10.1099/vir.0.82826-0" @default.
• W2001331132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17554032" @default.
• W2001331132 hasPublicationYear "2007" @default.
• W2001331132 type Work @default.
• W2001331132 sameAs 2001331132 @default.
• W2001331132 citedByCount "22" @default.
• W2001331132 countsByYear W20013311322012 @default.
• W2001331132 countsByYear W20013311322013 @default.
• W2001331132 countsByYear W20013311322014 @default.
• W2001331132 countsByYear W20013311322016 @default.
• W2001331132 countsByYear W20013311322017 @default.
• W2001331132 countsByYear W20013311322019 @default.
• W2001331132 countsByYear W20013311322021 @default.
• W2001331132 countsByYear W20013311322022 @default.
• W2001331132 crossrefType "journal-article" @default.
• W2001331132 hasAuthorship W2001331132A5033665234 @default.
• W2001331132 hasAuthorship W2001331132A5037546703 @default.
• W2001331132 hasAuthorship W2001331132A5041720192 @default.
• W2001331132 hasAuthorship W2001331132A5053120770 @default.
• W2001331132 hasAuthorship W2001331132A5054558829 @default.
• W2001331132 hasAuthorship W2001331132A5054826514 @default.
• W2001331132 hasAuthorship W2001331132A5054943079 @default.
• W2001331132 hasBestOaLocation W20013311321 @default.
• W2001331132 hasConcept C147483822 @default.
• W2001331132 hasConcept C151730666 @default.
• W2001331132 hasConcept C154317977 @default.
• W2001331132 hasConcept C159047783 @default.
• W2001331132 hasConcept C159654299 @default.
• W2001331132 hasConcept C167672396 @default.
• W2001331132 hasConcept C175156509 @default.
• W2001331132 hasConcept C188280979 @default.
• W2001331132 hasConcept C195616568 @default.
• W2001331132 hasConcept C202751555 @default.
• W2001331132 hasConcept C203014093 @default.
• W2001331132 hasConcept C2522874641 @default.
• W2001331132 hasConcept C2776090121 @default.
• W2001331132 hasConcept C2776408679 @default.
• W2001331132 hasConcept C2777103181 @default.
• W2001331132 hasConcept C2781463415 @default.
• W2001331132 hasConcept C43369102 @default.
• W2001331132 hasConcept C54355233 @default.
• W2001331132 hasConcept C86803240 @default.
• W2001331132 hasConcept C8891405 @default.
• W2001331132 hasConceptScore W2001331132C147483822 @default.
• W2001331132 hasConceptScore W2001331132C151730666 @default.
• W2001331132 hasConceptScore W2001331132C154317977 @default.
• W2001331132 hasConceptScore W2001331132C159047783 @default.
• W2001331132 hasConceptScore W2001331132C159654299 @default.
• W2001331132 hasConceptScore W2001331132C167672396 @default.
• W2001331132 hasConceptScore W2001331132C175156509 @default.
• W2001331132 hasConceptScore W2001331132C188280979 @default.
• W2001331132 hasConceptScore W2001331132C195616568 @default.
• W2001331132 hasConceptScore W2001331132C202751555 @default.
• W2001331132 hasConceptScore W2001331132C203014093 @default.
• W2001331132 hasConceptScore W2001331132C2522874641 @default.
• W2001331132 hasConceptScore W2001331132C2776090121 @default.
• W2001331132 hasConceptScore W2001331132C2776408679 @default.
• W2001331132 hasConceptScore W2001331132C2777103181 @default.
• W2001331132 hasConceptScore W2001331132C2781463415 @default.
• W2001331132 hasConceptScore W2001331132C43369102 @default.

• next