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- W2001338768 abstract "A series of novel cyclic amine-substituted benzoic acid derivatives were synthesized and evaluated for their PPARα agonist activity. Strucure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthyazole-5-carboxamido]piperidin-1-yl]benzoic acid (S)-4f (KRP-105) as a potent and high subtype-selective human PPARα agonist. (S)-4f showed excellent PK profile and oral administration of (S)-4f to high-fat diet dogs effectively lowered triglycerides." @default.
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- W2001338768 date "2012-01-01" @default.
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- W2001338768 title "Discovery of cyclic amine-substituted benzoic acids as PPARα agonists" @default.
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- W2001338768 doi "https://doi.org/10.1016/j.bmcl.2011.11.002" @default.
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