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• W2001344797 abstract "Ethylene:vinyl acetate pellets were loaded at 20°C by swelling the polymer with 1 and 3% (w/v) chloroformic solutions of tolbutamide. The energy dispersive X‐ray analysis showed different concentrations of the tolbutamide sulfur in the pellets sections according to the loading time. At the beginning of the loading process, the sulfur in the pellets showed two concentration peaks which later joined in the center of the section before reaching a homogeneous distribution. The concentration peaks might depend on a drug sieving process as the solution flow reaches a less swollen inner area. Therefore, the concentration distribution of the drug would be affected by the size of the polymer network, which is related to the volume of the solvent in the polymer. Another possible explanation of these concentration profiles is that they could be a result of the solvent evaporation process. The concentration distribution of the drug becomes homogeneous only after the complete swelling of all of the polymer." @default.
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• W2001344797 date "1989-01-01" @default.
• W2001344797 modified "2023-10-18" @default.
• W2001344797 title "Distribution of Drugs in Polymers Loaded by Swelling" @default.
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• W2001344797 doi "https://doi.org/10.1002/jps.2600780108" @default.
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