Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001359940> ?p ?o ?g. }
- W2001359940 endingPage "220" @default.
- W2001359940 startingPage "212" @default.
- W2001359940 abstract "In order to get insight into the mechanism of cadmium (Cd)-induced brain injury, we investigated the effects of Cd on the induction of COX-2 and ICAM-1 in bEnd.3 mouse brain endothelial cells (EC). Cd stimulated PGE2 release in a time and dose dependent manner, which was accompanied by increase of COX-2 expression. The thiol-reducing antioxidant N-acetylcyteine attenuated Cd-induced PGE2 production and COX-2 expression. Cd increased phosphorylation of p38 MAPK, but not of JNK and ERK1/2. A blockade of p38 MAPK pathway abrogated Cd-induced COX-2 expression and PGE2 production. Cd-induced ICAM-1 expression and leukocyte-EC adhesion were diminished by non-steroidal anti-inflammatory drugs such as indomethacin and NS-398, which was reversed by addition of PGE2. Together, these data suggest that Cd induces COX-2 expression through the activation of p38 MAPK, an oxidative stress-sensitive cellular signaling molecule, and induction of COX-2 is associated with ICAM-1 expression in brain endothelial cells following Cd exposure." @default.
- W2001359940 created "2016-06-24" @default.
- W2001359940 creator A5018035381 @default.
- W2001359940 creator A5033433353 @default.
- W2001359940 creator A5038108550 @default.
- W2001359940 creator A5043240094 @default.
- W2001359940 creator A5057738577 @default.
- W2001359940 creator A5061042137 @default.
- W2001359940 creator A5069884479 @default.
- W2001359940 creator A5084745684 @default.
- W2001359940 date "2006-09-10" @default.
- W2001359940 modified "2023-09-23" @default.
- W2001359940 title "COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells" @default.
- W2001359940 cites W1543238801 @default.
- W2001359940 cites W1560497272 @default.
- W2001359940 cites W1931473221 @default.
- W2001359940 cites W1969133124 @default.
- W2001359940 cites W1971200109 @default.
- W2001359940 cites W1974096418 @default.
- W2001359940 cites W1992460979 @default.
- W2001359940 cites W1995633773 @default.
- W2001359940 cites W1997644542 @default.
- W2001359940 cites W2012195580 @default.
- W2001359940 cites W2016760563 @default.
- W2001359940 cites W2030255962 @default.
- W2001359940 cites W2036062776 @default.
- W2001359940 cites W2036672952 @default.
- W2001359940 cites W2039096622 @default.
- W2001359940 cites W2041524207 @default.
- W2001359940 cites W2045831585 @default.
- W2001359940 cites W2047558574 @default.
- W2001359940 cites W2049212102 @default.
- W2001359940 cites W2049551689 @default.
- W2001359940 cites W2050383118 @default.
- W2001359940 cites W2050939682 @default.
- W2001359940 cites W2051200891 @default.
- W2001359940 cites W2073424941 @default.
- W2001359940 cites W2082176320 @default.
- W2001359940 cites W2084390160 @default.
- W2001359940 cites W2085951179 @default.
- W2001359940 cites W2088325460 @default.
- W2001359940 cites W2089371873 @default.
- W2001359940 cites W2101736298 @default.
- W2001359940 cites W2104579010 @default.
- W2001359940 cites W2116420880 @default.
- W2001359940 cites W2147830608 @default.
- W2001359940 cites W2154768453 @default.
- W2001359940 cites W2162419586 @default.
- W2001359940 cites W2164810943 @default.
- W2001359940 cites W2167692013 @default.
- W2001359940 cites W2172133526 @default.
- W2001359940 cites W22231678 @default.
- W2001359940 cites W2241195205 @default.
- W2001359940 doi "https://doi.org/10.1016/j.toxlet.2006.04.007" @default.
- W2001359940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16777358" @default.
- W2001359940 hasPublicationYear "2006" @default.
- W2001359940 type Work @default.
- W2001359940 sameAs 2001359940 @default.
- W2001359940 citedByCount "34" @default.
- W2001359940 countsByYear W20013599402012 @default.
- W2001359940 countsByYear W20013599402013 @default.
- W2001359940 countsByYear W20013599402014 @default.
- W2001359940 countsByYear W20013599402015 @default.
- W2001359940 countsByYear W20013599402016 @default.
- W2001359940 countsByYear W20013599402017 @default.
- W2001359940 countsByYear W20013599402018 @default.
- W2001359940 countsByYear W20013599402019 @default.
- W2001359940 countsByYear W20013599402021 @default.
- W2001359940 countsByYear W20013599402022 @default.
- W2001359940 countsByYear W20013599402023 @default.
- W2001359940 crossrefType "journal-article" @default.
- W2001359940 hasAuthorship W2001359940A5018035381 @default.
- W2001359940 hasAuthorship W2001359940A5033433353 @default.
- W2001359940 hasAuthorship W2001359940A5038108550 @default.
- W2001359940 hasAuthorship W2001359940A5043240094 @default.
- W2001359940 hasAuthorship W2001359940A5057738577 @default.
- W2001359940 hasAuthorship W2001359940A5061042137 @default.
- W2001359940 hasAuthorship W2001359940A5069884479 @default.
- W2001359940 hasAuthorship W2001359940A5084745684 @default.
- W2001359940 hasConcept C104317684 @default.
- W2001359940 hasConcept C11960822 @default.
- W2001359940 hasConcept C127561419 @default.
- W2001359940 hasConcept C153911025 @default.
- W2001359940 hasConcept C16224149 @default.
- W2001359940 hasConcept C185592680 @default.
- W2001359940 hasConcept C185946421 @default.
- W2001359940 hasConcept C2776151105 @default.
- W2001359940 hasConcept C51551487 @default.
- W2001359940 hasConcept C55493867 @default.
- W2001359940 hasConcept C57074206 @default.
- W2001359940 hasConcept C86803240 @default.
- W2001359940 hasConcept C95444343 @default.
- W2001359940 hasConceptScore W2001359940C104317684 @default.
- W2001359940 hasConceptScore W2001359940C11960822 @default.
- W2001359940 hasConceptScore W2001359940C127561419 @default.
- W2001359940 hasConceptScore W2001359940C153911025 @default.
- W2001359940 hasConceptScore W2001359940C16224149 @default.
- W2001359940 hasConceptScore W2001359940C185592680 @default.