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• W2001376776 abstract "R-837, a compound with no in vitro anti-HSV activity, was administered intravaginally to guinea pigs (5 mg/kg every 12 h) for five days beginning 12 h after genital HSV-2 inoculation. Drug treatment reduced vaginal viral replication (P<0.0001), completely protected against primary disease and reduced recurrent genital HSV disease (P<0.0001). Drug treatment also induced mild fever, weight loss, and decreased water intake. R-837 was a potent interferon inducer, which also induced variable enhancement of cell-mediated cytolytic activity against HSV-2 targets. Less than 36 h of vaginal HSV shedding was observed in animals with R-837 induced early enhancement of HSV-target cytolysis. Compared to placebo, R-837 decreased ELISA and ADCC antibody to HSV-2, but accelerated HSV-2 specific in vitro IL-2 production and peripheral blood mononuclear cell (PBMC) proliferation. R-837 exhibited potent anti-HSV activity in vivo apparently due to cytokine induction and enhancement of cell-mediated responses." @default.
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• W2001376776 date "1988-12-01" @default.
• W2001376776 modified "2023-10-15" @default.
• W2001376776 title "Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection" @default.
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• W2001376776 doi "https://doi.org/10.1016/0166-3542(88)90032-0" @default.
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