FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001384018> ?p ?o ?g. }

• W2001384018 abstract "Objective: To investigate the potential role of macrophage colony-stimulating factor (M-CSF) and macrophage colony-stimulating factor receptor (M-CSF-R) on the growth of human hepatoma cells. Methods: Specimens of different origin, including tissues of human hepatocellular carcinoma (HCC), human fetal liver (FL) and normal liver (NL), the hepatoma cell lines, as well as the peripheral blood mononuclear cells (PBMC) from patients with HCC or liver metastatic tumor (LMT), were used to detect the expression levels of M-CSF and M-CSF-R by ABC immunohistochemistry staining and reverse transcription polymerase chain reaction methods the expression levels of M-CSF and M-CSF-R. Influence of monoclonal antibody against M-CSF (B5) or M-CSF-R (RE2) on proliferation ability of hepatoma cell linesin vitro was also studied. Results: The results showed that hepatoma tissues produced elevated levels of both M-CSF and M-CSF-R compared with those of fetal liver (P<0.001). The M-CSF/M-CSF-R expression levels of PBMC from hepatoma patients were higher than those of LMT patients (P<0.01,P<0.05) and the normal people (P<0.001). The hepatoma cell lines showed strong positive for M-CSF and M-CSF-R production. Both B5 and RE2 displayed a dose-dependent inhibitory effect on the growth and proliferation of hepatoma cells. Conclusion: The study indicates a co-expression model for M-CSF-R in hepatoma cells, suggesting an involvement of M-CSF/M-CSF-R in growth signaling of those malignant cells. The M-CSF/M-CSF-R seems to function through an autonomy mechanism in human hepatoma." @default.
• W2001384018 created "2016-06-24" @default.
• W2001384018 creator A5013194838 @default.
• W2001384018 creator A5019373008 @default.
• W2001384018 creator A5020493393 @default.
• W2001384018 creator A5036680742 @default.
• W2001384018 creator A5070592741 @default.
• W2001384018 creator A5081950834 @default.
• W2001384018 creator A5084659091 @default.
• W2001384018 date "1999-06-01" @default.
• W2001384018 modified "2023-09-27" @default.
• W2001384018 title "Co-expression of macrophage colony-stimulating factor with its receptor in human hepatoma cells and its potential roles" @default.
• W2001384018 cites W1971972894 @default.
• W2001384018 cites W1971992475 @default.
• W2001384018 cites W2008457395 @default.
• W2001384018 cites W2013555005 @default.
• W2001384018 cites W2025732397 @default.
• W2001384018 cites W2031336219 @default.
• W2001384018 cites W2032825651 @default.
• W2001384018 cites W2033424543 @default.
• W2001384018 cites W2068961038 @default.
• W2001384018 cites W2069340309 @default.
• W2001384018 cites W2082365682 @default.
• W2001384018 cites W2407189645 @default.
• W2001384018 cites W2413056726 @default.
• W2001384018 cites W3148025011 @default.
• W2001384018 cites W33086918 @default.
• W2001384018 doi "https://doi.org/10.1007/bf02948442" @default.
• W2001384018 hasPublicationYear "1999" @default.
• W2001384018 type Work @default.
• W2001384018 sameAs 2001384018 @default.
• W2001384018 citedByCount "5" @default.
• W2001384018 crossrefType "journal-article" @default.
• W2001384018 hasAuthorship W2001384018A5013194838 @default.
• W2001384018 hasAuthorship W2001384018A5019373008 @default.
• W2001384018 hasAuthorship W2001384018A5020493393 @default.
• W2001384018 hasAuthorship W2001384018A5036680742 @default.
• W2001384018 hasAuthorship W2001384018A5070592741 @default.
• W2001384018 hasAuthorship W2001384018A5081950834 @default.
• W2001384018 hasAuthorship W2001384018A5084659091 @default.
• W2001384018 hasConcept C126322002 @default.
• W2001384018 hasConcept C137061746 @default.
• W2001384018 hasConcept C153911025 @default.
• W2001384018 hasConcept C159654299 @default.
• W2001384018 hasConcept C170493617 @default.
• W2001384018 hasConcept C172680121 @default.
• W2001384018 hasConcept C185592680 @default.
• W2001384018 hasConcept C202751555 @default.
• W2001384018 hasConcept C203014093 @default.
• W2001384018 hasConcept C204232928 @default.
• W2001384018 hasConcept C2778019345 @default.
• W2001384018 hasConcept C2779234561 @default.
• W2001384018 hasConcept C2779244956 @default.
• W2001384018 hasConcept C502942594 @default.
• W2001384018 hasConcept C50442881 @default.
• W2001384018 hasConcept C54355233 @default.
• W2001384018 hasConcept C55493867 @default.
• W2001384018 hasConcept C62112901 @default.
• W2001384018 hasConcept C71924100 @default.
• W2001384018 hasConcept C81885089 @default.
• W2001384018 hasConcept C86803240 @default.
• W2001384018 hasConceptScore W2001384018C126322002 @default.
• W2001384018 hasConceptScore W2001384018C137061746 @default.
• W2001384018 hasConceptScore W2001384018C153911025 @default.
• W2001384018 hasConceptScore W2001384018C159654299 @default.
• W2001384018 hasConceptScore W2001384018C170493617 @default.
• W2001384018 hasConceptScore W2001384018C172680121 @default.
• W2001384018 hasConceptScore W2001384018C185592680 @default.
• W2001384018 hasConceptScore W2001384018C202751555 @default.
• W2001384018 hasConceptScore W2001384018C203014093 @default.
• W2001384018 hasConceptScore W2001384018C204232928 @default.
• W2001384018 hasConceptScore W2001384018C2778019345 @default.
• W2001384018 hasConceptScore W2001384018C2779234561 @default.
• W2001384018 hasConceptScore W2001384018C2779244956 @default.
• W2001384018 hasConceptScore W2001384018C502942594 @default.
• W2001384018 hasConceptScore W2001384018C50442881 @default.
• W2001384018 hasConceptScore W2001384018C54355233 @default.
• W2001384018 hasConceptScore W2001384018C55493867 @default.
• W2001384018 hasConceptScore W2001384018C62112901 @default.
• W2001384018 hasConceptScore W2001384018C71924100 @default.
• W2001384018 hasConceptScore W2001384018C81885089 @default.
• W2001384018 hasConceptScore W2001384018C86803240 @default.
• W2001384018 hasLocation W20013840181 @default.
• W2001384018 hasOpenAccess W2001384018 @default.
• W2001384018 hasPrimaryLocation W20013840181 @default.
• W2001384018 hasRelatedWork W1547236510 @default.
• W2001384018 hasRelatedWork W1935446418 @default.
• W2001384018 hasRelatedWork W1997293662 @default.
• W2001384018 hasRelatedWork W2007118810 @default.
• W2001384018 hasRelatedWork W200953877 @default.
• W2001384018 hasRelatedWork W2032824187 @default.
• W2001384018 hasRelatedWork W2033142728 @default.
• W2001384018 hasRelatedWork W2050418030 @default.
• W2001384018 hasRelatedWork W2082466791 @default.
• W2001384018 hasRelatedWork W2084195647 @default.
• W2001384018 hasRelatedWork W2108006679 @default.
• W2001384018 hasRelatedWork W2133067740 @default.
• W2001384018 hasRelatedWork W2152111841 @default.
• W2001384018 hasRelatedWork W2338091983 @default.
• W2001384018 hasRelatedWork W2414812974 @default.

• next