FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001394891> ?p ?o ?g. }

• W2001394891 endingPage "1065" @default.
• W2001394891 startingPage "1058" @default.
• W2001394891 abstract "<b>Objective:</b> To use a case-control study to assess and compare patterns of gray matter loss across groups of subjects with different mutations in the microtubule-associated protein tau (<i>MAPT</i>) gene. <b>Methods:</b> We identified all subjects from Mayo Clinic, Rochester, Minnesota, that screened positive for mutations in <i>MAPT</i> and had a head MRI (n = 22). Voxel-based morphometry was used to assess patterns of gray matter atrophy in groups of subjects with the IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M mutations compared with age- and sex-matched controls. <b>Results:</b> All <i>MAPT</i> groups showed gray matter loss in the anterior temporal lobes, with varying degrees of involvement of the frontal and parietal lobes. Within the temporal lobe, the subjects with IVS10+16, IVS10+3, N279K, and S305N mutations (mutations that influence the alternative splicing of tau pre–messenger RNA) all showed gray matter loss focused on the medial temporal lobes. In contrast to these groups, the subjects with P301L or V337M mutations (mutations that affect the structure of the tau protein) both showed gray matter loss focused on the lateral temporal lobes, with a relative sparing of the medial temporal lobe. <b>Conclusion:</b> There seem to be differences in patterns of temporal lobe atrophy across the <i>MAPT</i> mutations, which may aid in the differentiation of the different mutation carriers. Furthermore, there seems to be a possible association between mutation function and pattern of temporal lobe atrophy." @default.
• W2001394891 created "2016-06-24" @default.
• W2001394891 creator A5005099850 @default.
• W2001394891 creator A5007824103 @default.
• W2001394891 creator A5022481370 @default.
• W2001394891 creator A5030267127 @default.
• W2001394891 creator A5048408999 @default.
• W2001394891 creator A5051295879 @default.
• W2001394891 creator A5053703908 @default.
• W2001394891 creator A5059027860 @default.
• W2001394891 creator A5065653107 @default.
• W2001394891 creator A5066352714 @default.
• W2001394891 creator A5089684856 @default.
• W2001394891 date "2009-09-28" @default.
• W2001394891 modified "2023-09-25" @default.
• W2001394891 title "Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations" @default.
• W2001394891 cites W1511517753 @default.
• W2001394891 cites W1970080715 @default.
• W2001394891 cites W1971621912 @default.
• W2001394891 cites W1974583546 @default.
• W2001394891 cites W1977257077 @default.
• W2001394891 cites W2004249343 @default.
• W2001394891 cites W2004901932 @default.
• W2001394891 cites W2012405577 @default.
• W2001394891 cites W2024941524 @default.
• W2001394891 cites W2028605133 @default.
• W2001394891 cites W2032273411 @default.
• W2001394891 cites W2034469326 @default.
• W2001394891 cites W2041922475 @default.
• W2001394891 cites W2049128488 @default.
• W2001394891 cites W2055679607 @default.
• W2001394891 cites W2059501379 @default.
• W2001394891 cites W2067507939 @default.
• W2001394891 cites W2072383054 @default.
• W2001394891 cites W2091592263 @default.
• W2001394891 cites W2105830106 @default.
• W2001394891 cites W2110388059 @default.
• W2001394891 cites W2119848633 @default.
• W2001394891 cites W2130152658 @default.
• W2001394891 cites W2134898935 @default.
• W2001394891 cites W2136250824 @default.
• W2001394891 cites W2145738501 @default.
• W2001394891 cites W2148079076 @default.
• W2001394891 cites W2154665893 @default.
• W2001394891 cites W2164891060 @default.
• W2001394891 cites W2410962966 @default.
• W2001394891 doi "https://doi.org/10.1212/wnl.0b013e3181b9c8b9" @default.
• W2001394891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754325" @default.
• W2001394891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19786698" @default.
• W2001394891 hasPublicationYear "2009" @default.
• W2001394891 type Work @default.
• W2001394891 sameAs 2001394891 @default.
• W2001394891 citedByCount "63" @default.
• W2001394891 countsByYear W20013948912012 @default.
• W2001394891 countsByYear W20013948912013 @default.
• W2001394891 countsByYear W20013948912014 @default.
• W2001394891 countsByYear W20013948912015 @default.
• W2001394891 countsByYear W20013948912016 @default.
• W2001394891 countsByYear W20013948912017 @default.
• W2001394891 countsByYear W20013948912018 @default.
• W2001394891 countsByYear W20013948912019 @default.
• W2001394891 countsByYear W20013948912020 @default.
• W2001394891 countsByYear W20013948912021 @default.
• W2001394891 countsByYear W20013948912022 @default.
• W2001394891 countsByYear W20013948912023 @default.
• W2001394891 crossrefType "journal-article" @default.
• W2001394891 hasAuthorship W2001394891A5005099850 @default.
• W2001394891 hasAuthorship W2001394891A5007824103 @default.
• W2001394891 hasAuthorship W2001394891A5022481370 @default.
• W2001394891 hasAuthorship W2001394891A5030267127 @default.
• W2001394891 hasAuthorship W2001394891A5048408999 @default.
• W2001394891 hasAuthorship W2001394891A5051295879 @default.
• W2001394891 hasAuthorship W2001394891A5053703908 @default.
• W2001394891 hasAuthorship W2001394891A5059027860 @default.
• W2001394891 hasAuthorship W2001394891A5065653107 @default.
• W2001394891 hasAuthorship W2001394891A5066352714 @default.
• W2001394891 hasAuthorship W2001394891A5089684856 @default.
• W2001394891 hasBestOaLocation W20013948912 @default.
• W2001394891 hasConcept C104317684 @default.
• W2001394891 hasConcept C126322002 @default.
• W2001394891 hasConcept C126838900 @default.
• W2001394891 hasConcept C142724271 @default.
• W2001394891 hasConcept C143409427 @default.
• W2001394891 hasConcept C15744967 @default.
• W2001394891 hasConcept C169760540 @default.
• W2001394891 hasConcept C2777127467 @default.
• W2001394891 hasConcept C2778180168 @default.
• W2001394891 hasConcept C2778186239 @default.
• W2001394891 hasConcept C2781099131 @default.
• W2001394891 hasConcept C2781172350 @default.
• W2001394891 hasConcept C2781192897 @default.
• W2001394891 hasConcept C501734568 @default.
• W2001394891 hasConcept C54355233 @default.
• W2001394891 hasConcept C71924100 @default.
• W2001394891 hasConcept C86803240 @default.
• W2001394891 hasConceptScore W2001394891C104317684 @default.
• W2001394891 hasConceptScore W2001394891C126322002 @default.
• W2001394891 hasConceptScore W2001394891C126838900 @default.

• next