Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001401116> ?p ?o ?g. }
- W2001401116 endingPage "337" @default.
- W2001401116 startingPage "332" @default.
- W2001401116 abstract "Purpose of review The survival curves for many pediatric sarcomas have remained flat for the past 2 decades or more and novel therapeutics – those small molecule medicines that selectively inhibit specific signaling molecules – have been slow to enter into pediatric practice. The preclinical basis for their use is reviewed here. Recent findings Preclinical and phase I studies showing efficacy of antiinsulin-like growth factor receptor 1 therapies for Ewing sarcoma have led to numerous ongoing clinical trials using these agents for Ewing and other sarcomas. Early studies of ERBB signaling as a target in sarcoma therapy have been tantalizing, but progress in this area has been controversial. In-vitro analysis of Src inhibitors suggested that these agents would prevent metastasis in osteosarcoma, whereas in-vivo analysis showed no effect on metastasis, underscoring the need for thorough preclinical investigations of promising new therapies to guide future clinical trials. Antiangiogenic and immunomodulatory therapies are gaining momentum in the pediatric arena and should be tested in combination with traditional cytotoxic agents for recurrent and high-risk primary pediatric sarcomas. Summary Pediatric sarcomas have diverse biology and distinct signaling pathways, making detailed preclinical evaluation of small molecule inhibitors essential to guiding the design of further clinical investigations." @default.
- W2001401116 created "2016-06-24" @default.
- W2001401116 creator A5077235997 @default.
- W2001401116 date "2009-07-01" @default.
- W2001401116 modified "2023-09-23" @default.
- W2001401116 title "Novel agents in development for pediatric sarcomas" @default.
- W2001401116 cites W1571073982 @default.
- W2001401116 cites W1856961639 @default.
- W2001401116 cites W1965097080 @default.
- W2001401116 cites W1975540192 @default.
- W2001401116 cites W1977616971 @default.
- W2001401116 cites W1978139448 @default.
- W2001401116 cites W1985750179 @default.
- W2001401116 cites W1992752045 @default.
- W2001401116 cites W1992755711 @default.
- W2001401116 cites W1997533142 @default.
- W2001401116 cites W1997888879 @default.
- W2001401116 cites W1999015953 @default.
- W2001401116 cites W1999030960 @default.
- W2001401116 cites W1999610606 @default.
- W2001401116 cites W2002403140 @default.
- W2001401116 cites W2003537331 @default.
- W2001401116 cites W2011017763 @default.
- W2001401116 cites W2011028805 @default.
- W2001401116 cites W2013699970 @default.
- W2001401116 cites W2019267750 @default.
- W2001401116 cites W2030502166 @default.
- W2001401116 cites W2032261242 @default.
- W2001401116 cites W2034770261 @default.
- W2001401116 cites W2038056960 @default.
- W2001401116 cites W2042660364 @default.
- W2001401116 cites W2045471398 @default.
- W2001401116 cites W2048248253 @default.
- W2001401116 cites W2050625644 @default.
- W2001401116 cites W2055624165 @default.
- W2001401116 cites W2061054148 @default.
- W2001401116 cites W2061440729 @default.
- W2001401116 cites W2062541630 @default.
- W2001401116 cites W2069622785 @default.
- W2001401116 cites W2073996882 @default.
- W2001401116 cites W2074413067 @default.
- W2001401116 cites W2074708554 @default.
- W2001401116 cites W2082501870 @default.
- W2001401116 cites W2101381508 @default.
- W2001401116 cites W2102820712 @default.
- W2001401116 cites W2102929879 @default.
- W2001401116 cites W2103405666 @default.
- W2001401116 cites W2104729679 @default.
- W2001401116 cites W2105687233 @default.
- W2001401116 cites W2107315486 @default.
- W2001401116 cites W2108188523 @default.
- W2001401116 cites W2109294408 @default.
- W2001401116 cites W2119391968 @default.
- W2001401116 cites W2120355275 @default.
- W2001401116 cites W2122608679 @default.
- W2001401116 cites W2123745849 @default.
- W2001401116 cites W2126783165 @default.
- W2001401116 cites W2128188903 @default.
- W2001401116 cites W2128271300 @default.
- W2001401116 cites W2129579482 @default.
- W2001401116 cites W2133403258 @default.
- W2001401116 cites W2135140338 @default.
- W2001401116 cites W2135870323 @default.
- W2001401116 cites W2137006197 @default.
- W2001401116 cites W2138309116 @default.
- W2001401116 cites W2143742430 @default.
- W2001401116 cites W2144991904 @default.
- W2001401116 cites W2146132090 @default.
- W2001401116 cites W2148971037 @default.
- W2001401116 cites W2149725504 @default.
- W2001401116 cites W2150613777 @default.
- W2001401116 cites W2152525323 @default.
- W2001401116 cites W2152786784 @default.
- W2001401116 cites W2160056156 @default.
- W2001401116 cites W2160425081 @default.
- W2001401116 cites W2162984113 @default.
- W2001401116 cites W2164452916 @default.
- W2001401116 cites W2167794986 @default.
- W2001401116 cites W2168159338 @default.
- W2001401116 cites W2169500410 @default.
- W2001401116 cites W2170793287 @default.
- W2001401116 cites W2171441333 @default.
- W2001401116 cites W4256105997 @default.
- W2001401116 doi "https://doi.org/10.1097/cco.0b013e32832c94e2" @default.
- W2001401116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19444103" @default.
- W2001401116 hasPublicationYear "2009" @default.
- W2001401116 type Work @default.
- W2001401116 sameAs 2001401116 @default.
- W2001401116 citedByCount "14" @default.
- W2001401116 countsByYear W20014011162012 @default.
- W2001401116 countsByYear W20014011162013 @default.
- W2001401116 countsByYear W20014011162014 @default.
- W2001401116 countsByYear W20014011162015 @default.
- W2001401116 countsByYear W20014011162018 @default.
- W2001401116 countsByYear W20014011162019 @default.
- W2001401116 countsByYear W20014011162021 @default.
- W2001401116 crossrefType "journal-article" @default.
- W2001401116 hasAuthorship W2001401116A5077235997 @default.