FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001431128> ?p ?o ?g. }

• W2001431128 endingPage "84" @default.
• W2001431128 startingPage "74" @default.
• W2001431128 abstract "There is a growing need for quantitative approaches to extrapolate relationships between chemical exposures and early biological perturbations from animals to humans given increasing use of biological assays to evaluate toxicity pathways. We have developed such an approach using polychlorinated biphenyls (PCBs) and thyroid hormone (TH) disruption as a case study. We reviewed and identified experimental animal literature from which we developed a low-dose, linear model of PCB body burdens and decrements in free thyroxine (FT(4)) and total thyroxine (TT(4)), accounting for 33 PCB congeners; extrapolated the dose-response from animals to humans; and compared the animal dose-response to the dose-response of PCB body burdens and TH changes from eleven human epidemiological studies. We estimated a range of potencies for PCB congeners (over 4 orders of magnitude), with the strongest for PCB 126. Our approach to developing toxic equivalency models produced relative potencies similar to the toxicity equivalency factors (TEFs) from the World Health Organization (WHO). We generally found that the dose-response extrapolated from the animal studies tends to under-predict the dose-response estimated from human epidemiological studies. A quantitative approach to evaluating the relationship between chemical exposures and TH perturbations, based on animal data can be used to assess human health consequences of thyroid toxicity and inform decision-making." @default.
• W2001431128 created "2016-06-24" @default.
• W2001431128 creator A5002184295 @default.
• W2001431128 creator A5008596041 @default.
• W2001431128 creator A5037201375 @default.
• W2001431128 creator A5044278440 @default.
• W2001431128 creator A5054226597 @default.
• W2001431128 creator A5077633544 @default.
• W2001431128 creator A5079081701 @default.
• W2001431128 creator A5079234992 @default.
• W2001431128 date "2012-07-01" @default.
• W2001431128 modified "2023-09-27" @default.
• W2001431128 title "Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans" @default.
• W2001431128 cites W1579194856 @default.
• W2001431128 cites W1970110882 @default.
• W2001431128 cites W1976228062 @default.
• W2001431128 cites W1986456272 @default.
• W2001431128 cites W1986530587 @default.
• W2001431128 cites W1989721362 @default.
• W2001431128 cites W1998513689 @default.
• W2001431128 cites W2003357955 @default.
• W2001431128 cites W2016480745 @default.
• W2001431128 cites W2025366218 @default.
• W2001431128 cites W2030278728 @default.
• W2001431128 cites W2032205612 @default.
• W2001431128 cites W2033022646 @default.
• W2001431128 cites W2051466065 @default.
• W2001431128 cites W2054343633 @default.
• W2001431128 cites W2057570773 @default.
• W2001431128 cites W2059317989 @default.
• W2001431128 cites W2064815058 @default.
• W2001431128 cites W2073147308 @default.
• W2001431128 cites W2091313766 @default.
• W2001431128 cites W2091720000 @default.
• W2001431128 cites W2096068920 @default.
• W2001431128 cites W2097104945 @default.
• W2001431128 cites W2104284672 @default.
• W2001431128 cites W2108397693 @default.
• W2001431128 cites W2112653650 @default.
• W2001431128 cites W2113451311 @default.
• W2001431128 cites W2113750680 @default.
• W2001431128 cites W2120454188 @default.
• W2001431128 cites W2125887504 @default.
• W2001431128 cites W2153393848 @default.
• W2001431128 cites W2158139019 @default.
• W2001431128 cites W2162798515 @default.
• W2001431128 cites W2163522982 @default.
• W2001431128 cites W2164762313 @default.
• W2001431128 cites W2168505716 @default.
• W2001431128 cites W2332489276 @default.
• W2001431128 doi "https://doi.org/10.1016/j.envres.2012.04.003" @default.
• W2001431128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4955584" @default.
• W2001431128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22575326" @default.
• W2001431128 hasPublicationYear "2012" @default.
• W2001431128 type Work @default.
• W2001431128 sameAs 2001431128 @default.
• W2001431128 citedByCount "11" @default.
• W2001431128 countsByYear W20014311282012 @default.
• W2001431128 countsByYear W20014311282013 @default.
• W2001431128 countsByYear W20014311282014 @default.
• W2001431128 countsByYear W20014311282015 @default.
• W2001431128 countsByYear W20014311282016 @default.
• W2001431128 countsByYear W20014311282017 @default.
• W2001431128 countsByYear W20014311282022 @default.
• W2001431128 crossrefType "journal-article" @default.
• W2001431128 hasAuthorship W2001431128A5002184295 @default.
• W2001431128 hasAuthorship W2001431128A5008596041 @default.
• W2001431128 hasAuthorship W2001431128A5037201375 @default.
• W2001431128 hasAuthorship W2001431128A5044278440 @default.
• W2001431128 hasAuthorship W2001431128A5054226597 @default.
• W2001431128 hasAuthorship W2001431128A5077633544 @default.
• W2001431128 hasAuthorship W2001431128A5079081701 @default.
• W2001431128 hasAuthorship W2001431128A5079234992 @default.
• W2001431128 hasBestOaLocation W20014311282 @default.
• W2001431128 hasConcept C12174686 @default.
• W2001431128 hasConcept C126322002 @default.
• W2001431128 hasConcept C134018914 @default.
• W2001431128 hasConcept C172268261 @default.
• W2001431128 hasConcept C197934379 @default.
• W2001431128 hasConcept C2777495288 @default.
• W2001431128 hasConcept C29730261 @default.
• W2001431128 hasConcept C2987857752 @default.
• W2001431128 hasConcept C3020000481 @default.
• W2001431128 hasConcept C33070731 @default.
• W2001431128 hasConcept C38652104 @default.
• W2001431128 hasConcept C41008148 @default.
• W2001431128 hasConcept C42407357 @default.
• W2001431128 hasConcept C42972112 @default.
• W2001431128 hasConcept C526584372 @default.
• W2001431128 hasConcept C71315377 @default.
• W2001431128 hasConcept C71924100 @default.
• W2001431128 hasConcept C86803240 @default.
• W2001431128 hasConcept C98274493 @default.
• W2001431128 hasConcept C99454951 @default.
• W2001431128 hasConceptScore W2001431128C12174686 @default.
• W2001431128 hasConceptScore W2001431128C126322002 @default.
• W2001431128 hasConceptScore W2001431128C134018914 @default.
• W2001431128 hasConceptScore W2001431128C172268261 @default.

• next