Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001462261> ?p ?o ?g. }
- W2001462261 endingPage "7" @default.
- W2001462261 startingPage "1" @default.
- W2001462261 abstract "The alternative synonymous codons in Corynebacterium glutamicum , a well-known bacterium used in industry for the production of amino acid, have been investigated by multivariate analysis. As C. glutamicum is a GC-rich organism, G and C are expected to predominate at the third position of codons. Indeed, overall codon usage analyses have indicated that C and/or G ending codons are predominant in this organism. Through multivariate statistical analysis, apart from mutational selection, we identified three other trends of codon usage variation among the genes. Firstly, the majority of highly expressed genes are scattered towards the positive end of the first axis, whereas the majority of lowly expressed genes are clustered towards the other end of the first axis. Furthermore, the distinct difference in the two sets of genes was that the C ending codons are predominate in putatively highly expressed genes, suggesting that the C ending codons are translationally optimal in this organism. Secondly, the majority of the putatively highly expressed genes have a tendency to locate on the leading strand, which indicates that replicational and transciptional selection might be invoked. Thirdly, highly expressed genes are more conserved than lowly expressed genes by synonymous and nonsynonymous substitutions among orthologous genes fromthe genomes of C. glutamicum and C. diphtheriae . We also analyzed other factors such as the length of genes and hydrophobicity that might influence codon usage and found their contributions to be weak." @default.
- W2001462261 created "2016-06-24" @default.
- W2001462261 creator A5002945666 @default.
- W2001462261 creator A5027650060 @default.
- W2001462261 creator A5079596808 @default.
- W2001462261 creator A5091235788 @default.
- W2001462261 date "2010-01-01" @default.
- W2001462261 modified "2023-10-18" @default.
- W2001462261 title "Codon Usage Patterns in<i>Corynebacterium glutamicum</i>: Mutational Bias, Natural Selection and Amino Acid Conservation" @default.
- W2001462261 cites W1489817806 @default.
- W2001462261 cites W1963900359 @default.
- W2001462261 cites W1965233192 @default.
- W2001462261 cites W1974358663 @default.
- W2001462261 cites W1979824030 @default.
- W2001462261 cites W1981053737 @default.
- W2001462261 cites W1989843988 @default.
- W2001462261 cites W1991141629 @default.
- W2001462261 cites W1996050521 @default.
- W2001462261 cites W1998038109 @default.
- W2001462261 cites W2000269014 @default.
- W2001462261 cites W2004674004 @default.
- W2001462261 cites W2005929281 @default.
- W2001462261 cites W2006390124 @default.
- W2001462261 cites W2023778561 @default.
- W2001462261 cites W2026208100 @default.
- W2001462261 cites W2034108516 @default.
- W2001462261 cites W2038941962 @default.
- W2001462261 cites W2059661284 @default.
- W2001462261 cites W2061136251 @default.
- W2001462261 cites W2063135364 @default.
- W2001462261 cites W2072180124 @default.
- W2001462261 cites W2075158468 @default.
- W2001462261 cites W2076793571 @default.
- W2001462261 cites W2078146553 @default.
- W2001462261 cites W2079818731 @default.
- W2001462261 cites W2080418977 @default.
- W2001462261 cites W2084550371 @default.
- W2001462261 cites W2086084754 @default.
- W2001462261 cites W2095868955 @default.
- W2001462261 cites W2100911486 @default.
- W2001462261 cites W2104316723 @default.
- W2001462261 cites W2110236168 @default.
- W2001462261 cites W2111752607 @default.
- W2001462261 cites W2114368970 @default.
- W2001462261 cites W2122545424 @default.
- W2001462261 cites W2122597216 @default.
- W2001462261 cites W2129324711 @default.
- W2001462261 cites W2141677147 @default.
- W2001462261 cites W2147126179 @default.
- W2001462261 cites W2154278477 @default.
- W2001462261 cites W2159595936 @default.
- W2001462261 cites W2163703477 @default.
- W2001462261 cites W2169303410 @default.
- W2001462261 cites W328784713 @default.
- W2001462261 doi "https://doi.org/10.1155/2010/343569" @default.
- W2001462261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860111" @default.
- W2001462261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20445740" @default.
- W2001462261 hasPublicationYear "2010" @default.
- W2001462261 type Work @default.
- W2001462261 sameAs 2001462261 @default.
- W2001462261 citedByCount "20" @default.
- W2001462261 countsByYear W20014622612012 @default.
- W2001462261 countsByYear W20014622612013 @default.
- W2001462261 countsByYear W20014622612014 @default.
- W2001462261 countsByYear W20014622612015 @default.
- W2001462261 countsByYear W20014622612016 @default.
- W2001462261 countsByYear W20014622612017 @default.
- W2001462261 countsByYear W20014622612018 @default.
- W2001462261 countsByYear W20014622612019 @default.
- W2001462261 countsByYear W20014622612020 @default.
- W2001462261 countsByYear W20014622612021 @default.
- W2001462261 countsByYear W20014622612022 @default.
- W2001462261 countsByYear W20014622612023 @default.
- W2001462261 crossrefType "journal-article" @default.
- W2001462261 hasAuthorship W2001462261A5002945666 @default.
- W2001462261 hasAuthorship W2001462261A5027650060 @default.
- W2001462261 hasAuthorship W2001462261A5079596808 @default.
- W2001462261 hasAuthorship W2001462261A5091235788 @default.
- W2001462261 hasBestOaLocation W20014622611 @default.
- W2001462261 hasConcept C104317684 @default.
- W2001462261 hasConcept C137858568 @default.
- W2001462261 hasConcept C138025448 @default.
- W2001462261 hasConcept C141231307 @default.
- W2001462261 hasConcept C149904235 @default.
- W2001462261 hasConcept C154945302 @default.
- W2001462261 hasConcept C195491092 @default.
- W2001462261 hasConcept C2776260651 @default.
- W2001462261 hasConcept C41008148 @default.
- W2001462261 hasConcept C501734568 @default.
- W2001462261 hasConcept C54355233 @default.
- W2001462261 hasConcept C70721500 @default.
- W2001462261 hasConcept C75563809 @default.
- W2001462261 hasConcept C81917197 @default.
- W2001462261 hasConcept C86803240 @default.
- W2001462261 hasConcept C87253356 @default.
- W2001462261 hasConceptScore W2001462261C104317684 @default.
- W2001462261 hasConceptScore W2001462261C137858568 @default.
- W2001462261 hasConceptScore W2001462261C138025448 @default.