FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001463369> ?p ?o ?g. }

• W2001463369 endingPage "923" @default.
• W2001463369 startingPage "917" @default.
• W2001463369 abstract "Zolpidem (Zol), an ω1-agonist, acts via GABAA receptors but may differ qualitatively from diazepam (Dz) and other benzodiazepines (BZDs). We conducted a placebo-controlled, randomized, double-blind, and crossover study to compare the psychomotor and cognitive effects of 15 mg Zol with those of 15 mg Dz, 30 mg oxazepam (Ox), 7.5 mg zopiclone (Zop), and ethanol (EOH; 0.65 + 0.35 g·kg−1) given to 12 subjects at 1-week intervals. Psychomotor tests (symbol digit substitution, simulated driving, flicker fusion, body sway) were done before and 1, 3.5, and 5 h after intake; immediate and delayed memory were measured between 1.5 and 3.5 h. The plasma concentrations of drugs were measured by gas chromatography and by radioreceptor assay (RRA). The mean values of EOH in blood at 1.5, 4, and 5.5 h were 0.82, 0.88, and 0.6 g·l−1, and the mean values of RRA-assayed plasma Dz were 470, 330, and 210 μg·l−1, respectively. The corresponding values of other hypnosedatives, in Dz equivalents (μg·l−1), were 550, 750, and 330 for Ox; 350, 270, and 70 for Zol; and 160, 210, and 70 for Zop. The standard RRA graph for Zol was significantly flatter than those for other hypnotics. Zol impaired coordinative, reactive, and cognitive skills at 1 and 3.5 h more clearly than the other agents did, the most sensitive performance (tracking) still being impaired by Zol at 5 h. Dz and Zop were less active than Zol objectively; subjective sedation after Dz and Zol was stronger than after Zop. Compared to placebo, all active agents tended to impair learning and memory, their decremental effects, in declining order, being Zol, Dz > EOH, Ox > Zop. During the delay, Dz and Zol caused similar losses of material that had been learned. When separating “true” delayed memory from immediate memory (attention important), Dz and Zol had equieffects on delayed memory and were more detrimental than Zop. When contrasting that against the impaired psychomotor performances, it is possible that 15 mg Zol impairs memory relatively less than 15 mg Dz does." @default.
• W2001463369 created "2016-06-24" @default.
• W2001463369 creator A5006063982 @default.
• W2001463369 creator A5024265800 @default.
• W2001463369 creator A5062447213 @default.
• W2001463369 creator A5070676255 @default.
• W2001463369 date "1998-04-01" @default.
• W2001463369 modified "2023-10-02" @default.
• W2001463369 title "Effects of Alcohol, Zolpidem, and Some Other Sedatives and Hypnotics on Human Performance and Memory" @default.
• W2001463369 cites W1991643196 @default.
• W2001463369 cites W2005020654 @default.
• W2001463369 cites W2009358137 @default.
• W2001463369 cites W2010503474 @default.
• W2001463369 cites W2011265603 @default.
• W2001463369 cites W2013433124 @default.
• W2001463369 cites W2014419597 @default.
• W2001463369 cites W2017231357 @default.
• W2001463369 cites W2020856989 @default.
• W2001463369 cites W2024905834 @default.
• W2001463369 cites W2026382218 @default.
• W2001463369 cites W2028912602 @default.
• W2001463369 cites W2031666449 @default.
• W2001463369 cites W2034433053 @default.
• W2001463369 cites W2036126511 @default.
• W2001463369 cites W2037424604 @default.
• W2001463369 cites W2071239669 @default.
• W2001463369 cites W2074167524 @default.
• W2001463369 cites W2075723143 @default.
• W2001463369 cites W2081938027 @default.
• W2001463369 cites W2082861010 @default.
• W2001463369 cites W2090713272 @default.
• W2001463369 cites W2092459398 @default.
• W2001463369 cites W2095684169 @default.
• W2001463369 cites W2134387881 @default.
• W2001463369 doi "https://doi.org/10.1016/s0091-3057(97)00506-6" @default.
• W2001463369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9586849" @default.
• W2001463369 hasPublicationYear "1998" @default.
• W2001463369 type Work @default.
• W2001463369 sameAs 2001463369 @default.
• W2001463369 citedByCount "71" @default.
• W2001463369 countsByYear W20014633692012 @default.
• W2001463369 countsByYear W20014633692013 @default.
• W2001463369 countsByYear W20014633692014 @default.
• W2001463369 countsByYear W20014633692015 @default.
• W2001463369 countsByYear W20014633692016 @default.
• W2001463369 countsByYear W20014633692017 @default.
• W2001463369 countsByYear W20014633692018 @default.
• W2001463369 countsByYear W20014633692020 @default.
• W2001463369 countsByYear W20014633692021 @default.
• W2001463369 countsByYear W20014633692022 @default.
• W2001463369 countsByYear W20014633692023 @default.
• W2001463369 crossrefType "journal-article" @default.
• W2001463369 hasAuthorship W2001463369A5006063982 @default.
• W2001463369 hasAuthorship W2001463369A5024265800 @default.
• W2001463369 hasAuthorship W2001463369A5062447213 @default.
• W2001463369 hasAuthorship W2001463369A5070676255 @default.
• W2001463369 hasConcept C142724271 @default.
• W2001463369 hasConcept C170493617 @default.
• W2001463369 hasConcept C185592680 @default.
• W2001463369 hasConcept C204787440 @default.
• W2001463369 hasConcept C27081682 @default.
• W2001463369 hasConcept C2776175493 @default.
• W2001463369 hasConcept C2776615572 @default.
• W2001463369 hasConcept C2776768635 @default.
• W2001463369 hasConcept C2777123777 @default.
• W2001463369 hasConcept C2777810057 @default.
• W2001463369 hasConcept C2778173252 @default.
• W2001463369 hasConcept C2780930544 @default.
• W2001463369 hasConcept C2781210498 @default.
• W2001463369 hasConcept C42219234 @default.
• W2001463369 hasConcept C55493867 @default.
• W2001463369 hasConcept C6557445 @default.
• W2001463369 hasConcept C71924100 @default.
• W2001463369 hasConcept C86803240 @default.
• W2001463369 hasConcept C87813604 @default.
• W2001463369 hasConcept C98274493 @default.
• W2001463369 hasConceptScore W2001463369C142724271 @default.
• W2001463369 hasConceptScore W2001463369C170493617 @default.
• W2001463369 hasConceptScore W2001463369C185592680 @default.
• W2001463369 hasConceptScore W2001463369C204787440 @default.
• W2001463369 hasConceptScore W2001463369C27081682 @default.
• W2001463369 hasConceptScore W2001463369C2776175493 @default.
• W2001463369 hasConceptScore W2001463369C2776615572 @default.
• W2001463369 hasConceptScore W2001463369C2776768635 @default.
• W2001463369 hasConceptScore W2001463369C2777123777 @default.
• W2001463369 hasConceptScore W2001463369C2777810057 @default.
• W2001463369 hasConceptScore W2001463369C2778173252 @default.
• W2001463369 hasConceptScore W2001463369C2780930544 @default.
• W2001463369 hasConceptScore W2001463369C2781210498 @default.
• W2001463369 hasConceptScore W2001463369C42219234 @default.
• W2001463369 hasConceptScore W2001463369C55493867 @default.
• W2001463369 hasConceptScore W2001463369C6557445 @default.
• W2001463369 hasConceptScore W2001463369C71924100 @default.
• W2001463369 hasConceptScore W2001463369C86803240 @default.
• W2001463369 hasConceptScore W2001463369C87813604 @default.
• W2001463369 hasConceptScore W2001463369C98274493 @default.
• W2001463369 hasIssue "4" @default.
• W2001463369 hasLocation W20014633691 @default.

• next