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• W2001463968 abstract "The aim was to evaluate effects of the therapy initiated at the day of admission on in-hospital mortality (HM) in patients with FMI - 5-year pilot registry (2003–2007) of six Czech small district hospitals referring patients for primary PCI to larger cathlab centers. The sample consisted of 2108 eligible patients, 56.2 men and 43.8 % women, aged 65.3 and 73.9 years, respectively. Their risk factors (RF) were (in %): hypertension (EH: 71.5), dyslipidemia (DLP: 44.9), diabetes (36.2) and smoking (27.2). There were 35.8 % STEMI and HM was 8.8 %. The previous therapy consisted of aspirin (ASA) in 28.7, β-blockers (BB) 32.1, ACEI/ARB 48.1 and statins in 13.9 % of patients. The odds of death (OD) increased with each year of age (1.1 in odds ratio – OR), influence of gender on death was not proven. Smoking was not significant as it was strongly negatively correlated with age. OD were associated especially with presence of heart failure (HF, OR = 3.5), DM (OR = 1.5) and STEMI compared to NSTEMI (OR = 4.1). The reperfusion therapy for STEMI decreased OD to the level of NSTEMI. Contrary to DM, the partially treated EH and DLP significantly reduced OD (both OR = 0.6). Aspirin (OR = 0.5), β-blockers (OR = 0.6) and statins (OR = 0.4) reduced OD. ACEI/ARB did not change OD (OR = 1.0) but reduced them significantly when used in HF (OR = 0.4). OD decreased with increasing number of recommended drugs – 1: OR = 0.55, 2: OR = 0.34, 3: OR = 0.15 and 4 drugs: OR = 0.10. The most frequent drug in monotherapy was ASA (23.8) and drug combinations ASA+BB (10.3), ASA+BB+statin (12.5) and ASA+BB+statin+ACEI/ARB (19.3 %). The therapy for both dyslipidemia and hypertension reduced OD below the risk level of normolipidemic and normotensive patiens with FMI. Due to the fact that the study is observational, the loss of RF significance could happen when a given therapy during hospitalization overwhelms its significance. The simultaneous use of aspirin, statin, β-blocker and ACEI/ARB reduced the odds of death in FMI to one tenth." @default.
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• W2001463968 date "2010-06-01" @default.
• W2001463968 modified "2023-10-15" @default.
• W2001463968 title "EFFECTS OF ANTIHYPERTENSIVE, HYPOLIPIDEMIC AND REPERFUSION THERAPY ON IN-HOSPITAL MORTALITY IN PREDOMINANTLY HYPERTENSIVE PATIENTS WITH THE FIRST MYOCARDIAL INFARCTION (FMI): PP.33.327" @default.
• W2001463968 doi "https://doi.org/10.1097/01.hjh.0000379865.37169.86" @default.
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