FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001467114> ?p ?o ?g. }

• W2001467114 endingPage "e19312" @default.
• W2001467114 startingPage "e19312" @default.
• W2001467114 abstract "Approximately half of known human miRNAs are located in the introns of protein coding genes. Some of these intronic miRNAs are only expressed when their host gene is and, as such, their steady state expression levels are highly correlated with those of the host gene's mRNA. Recently host gene expression levels have been used to predict the targets of intronic miRNAs by identifying other mRNAs that they have consistent negative correlation with. This is a potentially powerful approach because it allows a large number of expression profiling studies to be used but needs refinement because mRNAs can be targeted by multiple miRNAs and not all intronic miRNAs are co-expressed with their host genes.Here we introduce InMiR, a new computational method that uses a linear-Gaussian model to predict the targets of intronic miRNAs based on the expression profiles of their host genes across a large number of datasets. Our method recovers nearly twice as many true positives at the same fixed false positive rate as a comparable method that only considers correlations. Through an analysis of 140 Affymetrix datasets from Gene Expression Omnibus, we build a network of 19,926 interactions among 57 intronic miRNAs and 3,864 targets. InMiR can also predict which host genes have expression profiles that are good surrogates for those of their intronic miRNAs. Host genes that InMiR predicts are bad surrogates contain significantly more miRNA target sites in their 3' UTRs and are significantly more likely to have predicted Pol II and Pol III promoters in their introns.We provide a dataset of 1,935 predicted mRNA targets for 22 intronic miRNAs. These prediction are supported both by sequence features and expression. By combining our results with previous reports, we distinguish three classes of intronic miRNAs: Those that are tightly regulated with their host gene; those that are likely to be expressed from the same promoter but whose host gene is highly regulated by miRNAs; and those likely to have independent promoters." @default.
• W2001467114 created "2016-06-24" @default.
• W2001467114 creator A5029600247 @default.
• W2001467114 creator A5035010657 @default.
• W2001467114 creator A5084531219 @default.
• W2001467114 date "2011-06-09" @default.
• W2001467114 modified "2023-10-07" @default.
• W2001467114 title "Computational Prediction of Intronic microRNA Targets using Host Gene Expression Reveals Novel Regulatory Mechanisms" @default.
• W2001467114 cites W1963952972 @default.
• W2001467114 cites W1966241066 @default.
• W2001467114 cites W1971743295 @default.
• W2001467114 cites W1975437957 @default.
• W2001467114 cites W1977905073 @default.
• W2001467114 cites W1978337436 @default.
• W2001467114 cites W1986782449 @default.
• W2001467114 cites W1988163167 @default.
• W2001467114 cites W1988925753 @default.
• W2001467114 cites W1990868443 @default.
• W2001467114 cites W1994980424 @default.
• W2001467114 cites W2001630698 @default.
• W2001467114 cites W2009326616 @default.
• W2001467114 cites W2010763857 @default.
• W2001467114 cites W2011458493 @default.
• W2001467114 cites W2011879414 @default.
• W2001467114 cites W2012041376 @default.
• W2001467114 cites W2016294118 @default.
• W2001467114 cites W2026528132 @default.
• W2001467114 cites W2026570544 @default.
• W2001467114 cites W2034595398 @default.
• W2001467114 cites W2038303173 @default.
• W2001467114 cites W2039151962 @default.
• W2001467114 cites W2040191060 @default.
• W2001467114 cites W2041509376 @default.
• W2001467114 cites W2041825143 @default.
• W2001467114 cites W2043438785 @default.
• W2001467114 cites W2050869737 @default.
• W2001467114 cites W2059073003 @default.
• W2001467114 cites W2065566217 @default.
• W2001467114 cites W2068205681 @default.
• W2001467114 cites W2069795758 @default.
• W2001467114 cites W2070571588 @default.
• W2001467114 cites W2075110522 @default.
• W2001467114 cites W2077026063 @default.
• W2001467114 cites W2082171629 @default.
• W2001467114 cites W2089001345 @default.
• W2001467114 cites W2094253263 @default.
• W2001467114 cites W2096744132 @default.
• W2001467114 cites W2102840368 @default.
• W2001467114 cites W2105197182 @default.
• W2001467114 cites W2112192177 @default.
• W2001467114 cites W2113390076 @default.
• W2001467114 cites W2113942490 @default.
• W2001467114 cites W2125321800 @default.
• W2001467114 cites W2125818518 @default.
• W2001467114 cites W2126422513 @default.
• W2001467114 cites W2130674065 @default.
• W2001467114 cites W2130707276 @default.
• W2001467114 cites W2130979840 @default.
• W2001467114 cites W2133968430 @default.
• W2001467114 cites W2137350216 @default.
• W2001467114 cites W2142718844 @default.
• W2001467114 cites W2142976423 @default.
• W2001467114 cites W2146771296 @default.
• W2001467114 cites W2149785901 @default.
• W2001467114 cites W2150562727 @default.
• W2001467114 cites W2150591845 @default.
• W2001467114 cites W2151911276 @default.
• W2001467114 cites W2161149887 @default.
• W2001467114 cites W2162674813 @default.
• W2001467114 cites W2163199119 @default.
• W2001467114 cites W2164194749 @default.
• W2001467114 cites W2165675181 @default.
• W2001467114 cites W2169600668 @default.
• W2001467114 cites W2171230529 @default.
• W2001467114 doi "https://doi.org/10.1371/journal.pone.0019312" @default.
• W2001467114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3111417" @default.
• W2001467114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21694770" @default.
• W2001467114 hasPublicationYear "2011" @default.
• W2001467114 type Work @default.
• W2001467114 sameAs 2001467114 @default.
• W2001467114 citedByCount "37" @default.
• W2001467114 countsByYear W20014671142012 @default.
• W2001467114 countsByYear W20014671142013 @default.
• W2001467114 countsByYear W20014671142014 @default.
• W2001467114 countsByYear W20014671142015 @default.
• W2001467114 countsByYear W20014671142016 @default.
• W2001467114 countsByYear W20014671142017 @default.
• W2001467114 countsByYear W20014671142018 @default.
• W2001467114 countsByYear W20014671142019 @default.
• W2001467114 countsByYear W20014671142020 @default.
• W2001467114 countsByYear W20014671142022 @default.
• W2001467114 crossrefType "journal-article" @default.
• W2001467114 hasAuthorship W2001467114A5029600247 @default.
• W2001467114 hasAuthorship W2001467114A5035010657 @default.
• W2001467114 hasAuthorship W2001467114A5084531219 @default.
• W2001467114 hasBestOaLocation W20014671141 @default.
• W2001467114 hasConcept C104317684 @default.
• W2001467114 hasConcept C105565629 @default.

• next