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- W2001472511 abstract "Sex steroids are known to deeply alter processes other than fish reproduction, including fish growth, intermediary metabolism, osmoregulation and immunity. We have previously reported that 17β-estradiol (E2), the main fish estrogen, promotes the mobilization of acidophilic granulocytes from the head kidney, the bone marrow equivalent in fish, to the gonad in the bony fish gilthead seabream (Sparus aurata L.). The aim of this study was to investigate the effects of E2 and 17α-ethinylestradiol (EE2), an endocrine disruptor with strong estrogenic effects commonly found in the aquatic environment, on the ability of gilthead seabream endothelial cells (ECs) to promote leukocyte infiltration. E2 and EE2 were seen to affect ECs in different ways. Thus, E2 was able to increase the production of nitric oxide (NO) and up-regulate the expression of the key activation markers, interleukin-1β, CC chemokine ligand 4, interleukin-8, E-selectin and matrix metalloproteinase 9, when used alone or combined with bacterial DNA. In contrast, EE2 failed to affect NO release and reduced the up-regulation of the above genes promoted by bacterial DNA. Moreover, we found that leukocyte adhesion to ECs was enhanced by E2 treatment. Collectively, these results suggest that estrogens modulate fish leukocyte trafficking during an inflammatory process by activating ECs." @default.
- W2001472511 created "2016-06-24" @default.
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- W2001472511 date "2011-09-01" @default.
- W2001472511 modified "2023-10-16" @default.
- W2001472511 title "Natural and synthetic estrogens modulate the inflammatory response in the gilthead seabream (Sparus aurata L.) through the activation of endothelial cells" @default.
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- W2001472511 doi "https://doi.org/10.1016/j.molimm.2011.05.019" @default.
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