Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001490596> ?p ?o ?g. }
- W2001490596 endingPage "1107.e4" @default.
- W2001490596 startingPage "1100" @default.
- W2001490596 abstract "Eosinophilic esophagitis (EoE) is a chronic antigen-mediated disease characterized by esophageal eosinophilia, remodeling, and fibrosis. TGF-β1 is a central regulator of EoE remodeling and increases esophageal smooth muscle (ESM) cell contraction.In this study we aimed to understand the molecular mechanisms by which TGF-β1 could induce ESM cell contraction.We used primary human ESM cells and esophageal myofibroblasts (EMFs) to assess the mechanisms of TGF-β1-induced contraction. We analyzed the expression, phosphorylation, and function of phospholamban (PLN), a sarcoendoplasmic reticulum regulatory protein induced by TGF-β1. Expression of PLN, phospho-PLN, and its regulatory pathway was analyzed in the ESM of biopsy specimens from patients with EoE and control subjects. Gene silencing in EMFs from patients with EoE was used to understand the role of PLN in contraction.TGF-β1 induced and phosphorylated PLN in primary human ESM cells and EMFs from patients with EoE. PLN and phospho-PLN levels were increased in smooth muscle from patients with EoE compared with that seen in smooth muscle from control subjects in vivo. PLN inhibition significantly diminished TGF-β1-induced EMF contraction in patients with EoE. PLN expression and ESM/EMF contraction depended on TGF-β receptor I signals.We describe a previously unrecognized mechanism for ESM cell contraction that depends on TGF-β1, its receptors, and PLN. Because PLN levels are increased in smooth muscle from patients with EoE and PLN silencing diminishes contraction, we provide a novel potential mechanistic framework and therapeutic target for ESM dysfunction in patients with EoE." @default.
- W2001490596 created "2016-06-24" @default.
- W2001490596 creator A5001371295 @default.
- W2001490596 creator A5012660316 @default.
- W2001490596 creator A5029957076 @default.
- W2001490596 creator A5047493337 @default.
- W2001490596 creator A5057831374 @default.
- W2001490596 creator A5089210937 @default.
- W2001490596 date "2014-11-01" @default.
- W2001490596 modified "2023-09-23" @default.
- W2001490596 title "TGF-β1–induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis" @default.
- W2001490596 cites W1512442169 @default.
- W2001490596 cites W1583296450 @default.
- W2001490596 cites W169056187 @default.
- W2001490596 cites W1967193849 @default.
- W2001490596 cites W1967926844 @default.
- W2001490596 cites W1972428316 @default.
- W2001490596 cites W1972578247 @default.
- W2001490596 cites W1974997545 @default.
- W2001490596 cites W1981756521 @default.
- W2001490596 cites W1986415114 @default.
- W2001490596 cites W1995481725 @default.
- W2001490596 cites W1995638296 @default.
- W2001490596 cites W2005895346 @default.
- W2001490596 cites W2025208780 @default.
- W2001490596 cites W2026413483 @default.
- W2001490596 cites W2027736504 @default.
- W2001490596 cites W2028162059 @default.
- W2001490596 cites W2034820568 @default.
- W2001490596 cites W2035398507 @default.
- W2001490596 cites W2037823168 @default.
- W2001490596 cites W2045143786 @default.
- W2001490596 cites W2052339117 @default.
- W2001490596 cites W2054790299 @default.
- W2001490596 cites W2055198152 @default.
- W2001490596 cites W2063903627 @default.
- W2001490596 cites W2069688346 @default.
- W2001490596 cites W2075782740 @default.
- W2001490596 cites W2078475980 @default.
- W2001490596 cites W2078900266 @default.
- W2001490596 cites W2079587357 @default.
- W2001490596 cites W2094721591 @default.
- W2001490596 cites W2097683207 @default.
- W2001490596 cites W2099728164 @default.
- W2001490596 cites W2106387457 @default.
- W2001490596 cites W2109206507 @default.
- W2001490596 cites W2114942701 @default.
- W2001490596 cites W2130819716 @default.
- W2001490596 cites W2136965317 @default.
- W2001490596 cites W2139331439 @default.
- W2001490596 cites W2142089467 @default.
- W2001490596 cites W2158714558 @default.
- W2001490596 cites W2162142698 @default.
- W2001490596 cites W2162528206 @default.
- W2001490596 cites W2166436571 @default.
- W2001490596 cites W2169896046 @default.
- W2001490596 cites W4246100030 @default.
- W2001490596 cites W869585253 @default.
- W2001490596 doi "https://doi.org/10.1016/j.jaci.2014.04.004" @default.
- W2001490596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4231011" @default.
- W2001490596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24835503" @default.
- W2001490596 hasPublicationYear "2014" @default.
- W2001490596 type Work @default.
- W2001490596 sameAs 2001490596 @default.
- W2001490596 citedByCount "57" @default.
- W2001490596 countsByYear W20014905962015 @default.
- W2001490596 countsByYear W20014905962016 @default.
- W2001490596 countsByYear W20014905962017 @default.
- W2001490596 countsByYear W20014905962018 @default.
- W2001490596 countsByYear W20014905962019 @default.
- W2001490596 countsByYear W20014905962020 @default.
- W2001490596 countsByYear W20014905962021 @default.
- W2001490596 countsByYear W20014905962022 @default.
- W2001490596 countsByYear W20014905962023 @default.
- W2001490596 crossrefType "journal-article" @default.
- W2001490596 hasAuthorship W2001490596A5001371295 @default.
- W2001490596 hasAuthorship W2001490596A5012660316 @default.
- W2001490596 hasAuthorship W2001490596A5029957076 @default.
- W2001490596 hasAuthorship W2001490596A5047493337 @default.
- W2001490596 hasAuthorship W2001490596A5057831374 @default.
- W2001490596 hasAuthorship W2001490596A5089210937 @default.
- W2001490596 hasBestOaLocation W20014905962 @default.
- W2001490596 hasConcept C11960822 @default.
- W2001490596 hasConcept C126322002 @default.
- W2001490596 hasConcept C134018914 @default.
- W2001490596 hasConcept C163415756 @default.
- W2001490596 hasConcept C17137333 @default.
- W2001490596 hasConcept C2779134260 @default.
- W2001490596 hasConcept C2780559512 @default.
- W2001490596 hasConcept C2781065132 @default.
- W2001490596 hasConcept C502942594 @default.
- W2001490596 hasConcept C71924100 @default.
- W2001490596 hasConcept C86803240 @default.
- W2001490596 hasConcept C95444343 @default.
- W2001490596 hasConceptScore W2001490596C11960822 @default.
- W2001490596 hasConceptScore W2001490596C126322002 @default.
- W2001490596 hasConceptScore W2001490596C134018914 @default.
- W2001490596 hasConceptScore W2001490596C163415756 @default.