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• W2001495004 abstract "To evaluate the penetration of the blood–brain barrier by 9-fluoropropyl-(+)-dihydrotetrabenazine (AV-133), microdialysis probes were implanted simultaneously into rat blood and brain, and a liquid chromatography–tandem mass spectrometric method was developed and validated to monitor the AV-133 concentration in the microdialysates. The chromatographic separation was performed on an XTerra C18 column (150 mm × 2.1 mm i.d., 5 μm particles) with gradient elution. The mass spectrometer was operated in positive mode using electrospray ionization. The analytes were measured using the multiple-reaction-monitoring mode. The calibration curves were linear over the range of 5.00–1000 ng/mL AV-133, with a coefficient of determination >0.995. The accuracies ranged from 99.5% to 105.0% and the precisions were <10% for AV-133. This method was used to determine the concentrations of AV-133 and its pharmacokinetics in the brains and blood of rats. The blood and brain concentration–time profiles for AV-133 were obtained, and the blood–brain barrier penetration was evaluated." @default.
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• W2001495004 date "2011-10-01" @default.
• W2001495004 modified "2023-10-07" @default.
• W2001495004 title "Determination of the penetration of 9-fluoropropyl-(+)-dihydrotetrabenazine across the blood–brain barrier in rats by microdialysis combined with liquid chromatography–tandem mass spectrometry" @default.
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• W2001495004 doi "https://doi.org/10.1016/j.jchromb.2011.08.043" @default.
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