Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001504673> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2001504673 endingPage "1450" @default.
- W2001504673 startingPage "1445" @default.
- W2001504673 abstract "Three kinds of structural disturbances were found in an 88 base pair (bp) fragment of phi X-174 DNA after exposure to N-acetoxy-N-2-acetylaminofluorene (N-Aco-AAF). (i) Frequent strand scissions at two specific guanine sites on the 5' 32P-end-labeled fragment were identified by base sequence analysis. Scissions at these two sites were induced at neutral pH and they were not increased by treatment with apurinic endonuclease. They are an immediate consequence of N-Aco-AAF action and are not primarily apurinic sites. (ii) Alkali treatment with 1 M piperidine at 90 degrees C induced strand scissions at every guanine, demonstrating adduct slices, depurination and strand scissions. (iii) Adducted DNA was sensitive to single-strand specific nuclease digestion, suggesting unwound DNA. These studies indicate the prediliction of N-Aco-AAF for certain DNA sites and they suggest three kinds of DNA modifications which can be expected after adduction by this carcinogen. Some of the sites may be premutational carcinogen-induced DNA structural modifications." @default.
- W2001504673 created "2016-06-24" @default.
- W2001504673 creator A5008491972 @default.
- W2001504673 creator A5013128377 @default.
- W2001504673 creator A5020511780 @default.
- W2001504673 date "1983-01-01" @default.
- W2001504673 modified "2023-09-27" @default.
- W2001504673 title "Site specific cleavage of <i>φ</i>X-174 replicative form DNA after modification by N-acetoxy-N-2-acetylaminofluorene" @default.
- W2001504673 doi "https://doi.org/10.1093/carcin/4.11.1445" @default.
- W2001504673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6227423" @default.
- W2001504673 hasPublicationYear "1983" @default.
- W2001504673 type Work @default.
- W2001504673 sameAs 2001504673 @default.
- W2001504673 citedByCount "13" @default.
- W2001504673 crossrefType "journal-article" @default.
- W2001504673 hasAuthorship W2001504673A5008491972 @default.
- W2001504673 hasAuthorship W2001504673A5013128377 @default.
- W2001504673 hasAuthorship W2001504673A5020511780 @default.
- W2001504673 hasBestOaLocation W20015046731 @default.
- W2001504673 hasConcept C104317684 @default.
- W2001504673 hasConcept C114246631 @default.
- W2001504673 hasConcept C143425029 @default.
- W2001504673 hasConcept C150777479 @default.
- W2001504673 hasConcept C151730666 @default.
- W2001504673 hasConcept C153911025 @default.
- W2001504673 hasConcept C175156509 @default.
- W2001504673 hasConcept C181199279 @default.
- W2001504673 hasConcept C185581394 @default.
- W2001504673 hasConcept C185592680 @default.
- W2001504673 hasConcept C2777028655 @default.
- W2001504673 hasConcept C2777271071 @default.
- W2001504673 hasConcept C2778301229 @default.
- W2001504673 hasConcept C2779838395 @default.
- W2001504673 hasConcept C34737976 @default.
- W2001504673 hasConcept C43369102 @default.
- W2001504673 hasConcept C512185932 @default.
- W2001504673 hasConcept C552990157 @default.
- W2001504673 hasConcept C55493867 @default.
- W2001504673 hasConcept C71240020 @default.
- W2001504673 hasConcept C86803240 @default.
- W2001504673 hasConcept C87644729 @default.
- W2001504673 hasConceptScore W2001504673C104317684 @default.
- W2001504673 hasConceptScore W2001504673C114246631 @default.
- W2001504673 hasConceptScore W2001504673C143425029 @default.
- W2001504673 hasConceptScore W2001504673C150777479 @default.
- W2001504673 hasConceptScore W2001504673C151730666 @default.
- W2001504673 hasConceptScore W2001504673C153911025 @default.
- W2001504673 hasConceptScore W2001504673C175156509 @default.
- W2001504673 hasConceptScore W2001504673C181199279 @default.
- W2001504673 hasConceptScore W2001504673C185581394 @default.
- W2001504673 hasConceptScore W2001504673C185592680 @default.
- W2001504673 hasConceptScore W2001504673C2777028655 @default.
- W2001504673 hasConceptScore W2001504673C2777271071 @default.
- W2001504673 hasConceptScore W2001504673C2778301229 @default.
- W2001504673 hasConceptScore W2001504673C2779838395 @default.
- W2001504673 hasConceptScore W2001504673C34737976 @default.
- W2001504673 hasConceptScore W2001504673C43369102 @default.
- W2001504673 hasConceptScore W2001504673C512185932 @default.
- W2001504673 hasConceptScore W2001504673C552990157 @default.
- W2001504673 hasConceptScore W2001504673C55493867 @default.
- W2001504673 hasConceptScore W2001504673C71240020 @default.
- W2001504673 hasConceptScore W2001504673C86803240 @default.
- W2001504673 hasConceptScore W2001504673C87644729 @default.
- W2001504673 hasIssue "11" @default.
- W2001504673 hasLocation W20015046731 @default.
- W2001504673 hasLocation W20015046732 @default.
- W2001504673 hasOpenAccess W2001504673 @default.
- W2001504673 hasPrimaryLocation W20015046731 @default.
- W2001504673 hasRelatedWork W1966321456 @default.
- W2001504673 hasRelatedWork W1992068610 @default.
- W2001504673 hasRelatedWork W2001504673 @default.
- W2001504673 hasRelatedWork W2012619159 @default.
- W2001504673 hasRelatedWork W2032437796 @default.
- W2001504673 hasRelatedWork W2063994948 @default.
- W2001504673 hasRelatedWork W2064786538 @default.
- W2001504673 hasRelatedWork W2085873170 @default.
- W2001504673 hasRelatedWork W2096338604 @default.
- W2001504673 hasRelatedWork W3138344516 @default.
- W2001504673 hasVolume "4" @default.
- W2001504673 isParatext "false" @default.
- W2001504673 isRetracted "false" @default.
- W2001504673 magId "2001504673" @default.
- W2001504673 workType "article" @default.