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• W2001510915 abstract "L’inflammation allergique est considérée comme le résultat d’une activation des lymphocytes Th2. Pourtant cette inflammation, pertinente pour l’atopie et la présence des éosinophiles dans les tissus atteints, est insuffisante pour expliquer l’asthme. Plusieurs travaux ont montré qu’à l’inflammation de type Th2, était associée dans l’asthme une inflammation Th1 avec production d’IFN-gamma. Par ailleurs il a été montré récemment que des lymphocytes T dits régulateurs (Treg), producteurs d’IL-10 et/ou de TGF-beta et inducteurs de tolérance étaient déficitaires chez les sujets allergiques. De plus, ces lymphocytes augmentent lors de l’immunothérapie spécifique. Leur diminution pourrait rendre compte de l’activation Th2 rencontrée chez l’atopique. Dans cette courte revue, nous faisons le point sur l’importance potentielle des Treg dans l’atopie et l’asthme. Nous proposons un concept selon lequel la réaction inflammatoire allergique ne repose pas sur la rupture d’une balance Th1/Th2 mais sur un déficit en Treg. Ce déficit serait progressivement croissant du sujet normal à l’atopique, de l’atopie à l’asthme et de l’asthme à l’exacerbation. Trois dimensions de l’inflammation sont alors à prendre en compte : Th1, Th2, Treg. Allergic inflammation is considered to be the result of a pattern of Th2 lymphocyte activation. However this inflammation, relevant for atopy and infiltration of affected tissues by eosinophils, is insufficient by itself to explain the clinical features of asthma. Several studies have demonstrated that Th2 type inflammation was also associated in asthma with a Th1 response, with production of gamma interferon. It has recently been shown that the regulatory T lymphocytes (Treg) which produce IL-10 and/or TGF-beta and induce tolerance are defective in allergic patients. In addition, these lymphocytes increase during specific immunotherapy. Their decrease could explain the Th2 activation found in atopic patients. We review the potential importance of Treg cells in atopy and also asthma, and propose a concept whereby the allergic inflammatory response would not be due to a Th1/Th2 imbalance, but rather to a Treg deficiency progressively rising from normal to atopic, from atopy to asthma and from asthma to acute exacerbations. Three dimensions of inflammation need therefore to be taken into account: Th1, Th2 and Treg." @default.
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• W2001510915 date "2005-04-01" @default.
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• W2001510915 title "Lymphocytes T régulateurs, atopie et asthme : un nouveau concept en trois dimensions" @default.
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• W2001510915 doi "https://doi.org/10.1016/s0761-8425(05)85482-8" @default.
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