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• W2001515311 startingPage "633" @default.
• W2001515311 abstract "Cell death inhibition is a very successful strategy that cancer cells employ to combat the immune system and various anticancer therapies. Inhibitor of apoptosis (IAP) proteins possess a wide range of biological activities that promote cancer survival and proliferation. One of them, X-chromosome-linked IAP is a direct inhibitor of proapoptotic executioners, caspases. Cellular IAP proteins regulate expression of antiapoptotic molecules and prevent assembly of proapoptotic protein signaling complexes, while survivin regulates cell division. In addition, amplifications, mutations and chromosomal translocations of IAP genes are associated with various malignancies. Several therapeutic strategies have been designed to target IAP proteins, including a small-molecule approach that is based on mimicking the IAP-binding motif of an endogenous IAP antagonist – the second mitochondrial activator of caspases. Other strategies involve antisense nucleotides and transcriptional repression. The main focus of this article is to provide an update on IAP protein biology and perspectives on the development of IAP-targeting therapeutics." @default.
• W2001515311 created "2016-06-24" @default.
• W2001515311 creator A5048067233 @default.
• W2001515311 creator A5052364035 @default.
• W2001515311 date "2011-05-01" @default.
• W2001515311 modified "2023-10-18" @default.
• W2001515311 title "Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets" @default.
• W2001515311 cites W1492587973 @default.
• W2001515311 cites W1501881225 @default.
• W2001515311 cites W1520695706 @default.
• W2001515311 cites W1618299283 @default.
• W2001515311 cites W1778624427 @default.
• W2001515311 cites W1881072801 @default.
• W2001515311 cites W1942297882 @default.
• W2001515311 cites W1961949729 @default.
• W2001515311 cites W1962878424 @default.
• W2001515311 cites W1965020333 @default.
• W2001515311 cites W1966472904 @default.
• W2001515311 cites W1966798559 @default.
• W2001515311 cites W1967894078 @default.
• W2001515311 cites W1969796729 @default.
• W2001515311 cites W1971411560 @default.
• W2001515311 cites W1973462203 @default.
• W2001515311 cites W1973562447 @default.
• W2001515311 cites W1974768393 @default.
• W2001515311 cites W1976141746 @default.
• W2001515311 cites W1976353819 @default.
• W2001515311 cites W1976935037 @default.
• W2001515311 cites W1977258127 @default.
• W2001515311 cites W1979032223 @default.
• W2001515311 cites W1982384929 @default.
• W2001515311 cites W1984909958 @default.
• W2001515311 cites W1986048086 @default.
• W2001515311 cites W1986312997 @default.
• W2001515311 cites W1986320887 @default.
• W2001515311 cites W1986978728 @default.
• W2001515311 cites W1987241739 @default.
• W2001515311 cites W1987531976 @default.
• W2001515311 cites W1987868209 @default.
• W2001515311 cites W1989277510 @default.
• W2001515311 cites W1989726571 @default.
• W2001515311 cites W1990089954 @default.
• W2001515311 cites W1990683719 @default.
• W2001515311 cites W1991455654 @default.
• W2001515311 cites W1994851993 @default.
• W2001515311 cites W1998198750 @default.
• W2001515311 cites W1999660608 @default.
• W2001515311 cites W2000623989 @default.
• W2001515311 cites W2003926188 @default.
• W2001515311 cites W2003997716 @default.
• W2001515311 cites W2004206170 @default.
• W2001515311 cites W2005531064 @default.
• W2001515311 cites W2005572311 @default.
• W2001515311 cites W2006077720 @default.
• W2001515311 cites W2007071412 @default.
• W2001515311 cites W2007625252 @default.
• W2001515311 cites W2008181517 @default.
• W2001515311 cites W2008443832 @default.
• W2001515311 cites W2008596036 @default.
• W2001515311 cites W2008646773 @default.
• W2001515311 cites W2008993687 @default.
• W2001515311 cites W2010428875 @default.
• W2001515311 cites W2013801793 @default.
• W2001515311 cites W2013933514 @default.
• W2001515311 cites W2025522492 @default.
• W2001515311 cites W2027737461 @default.
• W2001515311 cites W2028330103 @default.
• W2001515311 cites W2028359994 @default.
• W2001515311 cites W2029595161 @default.
• W2001515311 cites W2030262603 @default.
• W2001515311 cites W2031949901 @default.
• W2001515311 cites W2032575813 @default.
• W2001515311 cites W2033914606 @default.
• W2001515311 cites W2035493275 @default.
• W2001515311 cites W2035919241 @default.
• W2001515311 cites W2036023206 @default.
• W2001515311 cites W2037249620 @default.
• W2001515311 cites W2039597975 @default.
• W2001515311 cites W2040370168 @default.
• W2001515311 cites W2040993067 @default.
• W2001515311 cites W2041629876 @default.
• W2001515311 cites W2042087846 @default.
• W2001515311 cites W2042409437 @default.
• W2001515311 cites W2042872424 @default.
• W2001515311 cites W2043817378 @default.
• W2001515311 cites W2045321300 @default.
• W2001515311 cites W2045383577 @default.
• W2001515311 cites W2048593328 @default.
• W2001515311 cites W2052605153 @default.
• W2001515311 cites W2053308358 @default.
• W2001515311 cites W2054559365 @default.
• W2001515311 cites W2054717287 @default.
• W2001515311 cites W2056143078 @default.
• W2001515311 cites W2057493177 @default.
• W2001515311 cites W2058617759 @default.
• W2001515311 cites W2060945380 @default.
• W2001515311 cites W2061561620 @default.
• W2001515311 cites W2063110724 @default.

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