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- W2001518591 abstract "Chlordiazepoxide (Librium) plasma concentrations were determined in a group of eleven subjects by a gas chromatographic method involving the use of an electron capture detector. The drug was extracted from 1 ml of alkalinized plasma in n-heptane containing 1.5% of isoamyl alcohol. Determination of plasma concentrations following administration of oral doses of 20 mg or more pro die was achieved by injecting directly into the chromatograph aliquots of this heptane extract. At lower doses, plasma levels were determined after re-extracting the drug from the heptane into small volumes of aqueous and organic solvents. The two known metabolites of the drug, the lactam and N-desmethyl chlordiazepoxide, did not interfere with the analysis of the unmetabolized compound, nor did a number of other psychotropic drugs analyzed according to the procedure described. The response of the electron capture detector to amounts of chlordiazepoxide as low as 0.5 ng permits the determination of the drug in 1-ml plasma samples after administration of a single 5-mg dose. Chlordiazepoxide plasma concentrations encountered in the samples analyzed ranged from 17 μg-% after ingestion of a single 5-mg dose to 689 μg-% following administration of multiple 50-mg doses." @default.
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- W2001518591 date "1971-01-01" @default.
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- W2001518591 title "Determination of chlordiazeporide plasma concentrations by electron capture gas-liquid chromatography" @default.
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- W2001518591 doi "https://doi.org/10.1016/s0021-9673(00)92416-6" @default.
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