Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001525541> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2001525541 endingPage "123" @default.
- W2001525541 startingPage "115" @default.
- W2001525541 abstract "The pharmacodynamics of three corticosteroids were investigated after intravenous administration of the phosphate esters of methylprednisolone, dexamethasone, and triamcinolone acetonide to healthy subjects at 20, 50, and 80 mg as well as placebo. Twenty-two different pharmacodynamic parameters were followed as a function of time for 48 hours. Statistically significant effects of the glucocorticoids were an increase in blood glucose levels, a decrease in the number of lymphocytes, eosinophils, basophils, and monocytes, and an increase in the number of granulocytes and stab cells. For the most significant pharmacodynamic effects (lymphocytes, granulocytes, and glucose) a previously derived integrated pharmacokinetic/pharmacodynamic model using plasma concentrations, protein-binding data, and in vitro receptor-binding affinities was used to predict the pharmacodynamic effect-time profiles. Good agreement of predicted and measured effects was observed, confirming the validity of the model. The clinical significance of the model was demonstrated by comparison of model-predicted maintenance doses with empirically determined clinical equivalency doses." @default.
- W2001525541 created "2016-06-24" @default.
- W2001525541 creator A5022031392 @default.
- W2001525541 creator A5025247074 @default.
- W2001525541 creator A5033045204 @default.
- W2001525541 creator A5033732811 @default.
- W2001525541 creator A5038022580 @default.
- W2001525541 creator A5060205272 @default.
- W2001525541 creator A5078634243 @default.
- W2001525541 date "1993-02-01" @default.
- W2001525541 modified "2023-10-03" @default.
- W2001525541 title "Receptor-Based Pharmacokinetic-Pharmacodynamic Analysis of Corticosteroids" @default.
- W2001525541 cites W1600397741 @default.
- W2001525541 cites W173079775 @default.
- W2001525541 cites W1967058567 @default.
- W2001525541 cites W2002431198 @default.
- W2001525541 cites W2011669550 @default.
- W2001525541 cites W2035495051 @default.
- W2001525541 cites W2070772930 @default.
- W2001525541 cites W2076863034 @default.
- W2001525541 cites W2078865702 @default.
- W2001525541 cites W2099829129 @default.
- W2001525541 cites W2131716231 @default.
- W2001525541 cites W2154889019 @default.
- W2001525541 doi "https://doi.org/10.1002/j.1552-4604.1993.tb03930.x" @default.
- W2001525541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8440759" @default.
- W2001525541 hasPublicationYear "1993" @default.
- W2001525541 type Work @default.
- W2001525541 sameAs 2001525541 @default.
- W2001525541 citedByCount "124" @default.
- W2001525541 countsByYear W20015255412012 @default.
- W2001525541 countsByYear W20015255412013 @default.
- W2001525541 countsByYear W20015255412014 @default.
- W2001525541 countsByYear W20015255412015 @default.
- W2001525541 countsByYear W20015255412016 @default.
- W2001525541 countsByYear W20015255412017 @default.
- W2001525541 countsByYear W20015255412018 @default.
- W2001525541 countsByYear W20015255412019 @default.
- W2001525541 countsByYear W20015255412020 @default.
- W2001525541 countsByYear W20015255412021 @default.
- W2001525541 countsByYear W20015255412022 @default.
- W2001525541 countsByYear W20015255412023 @default.
- W2001525541 crossrefType "journal-article" @default.
- W2001525541 hasAuthorship W2001525541A5022031392 @default.
- W2001525541 hasAuthorship W2001525541A5025247074 @default.
- W2001525541 hasAuthorship W2001525541A5033045204 @default.
- W2001525541 hasAuthorship W2001525541A5033732811 @default.
- W2001525541 hasAuthorship W2001525541A5038022580 @default.
- W2001525541 hasAuthorship W2001525541A5060205272 @default.
- W2001525541 hasAuthorship W2001525541A5078634243 @default.
- W2001525541 hasConcept C111113717 @default.
- W2001525541 hasConcept C112705442 @default.
- W2001525541 hasConcept C126322002 @default.
- W2001525541 hasConcept C170493617 @default.
- W2001525541 hasConcept C203014093 @default.
- W2001525541 hasConcept C2776804153 @default.
- W2001525541 hasConcept C2778903070 @default.
- W2001525541 hasConcept C2780372218 @default.
- W2001525541 hasConcept C2780401358 @default.
- W2001525541 hasConcept C59493245 @default.
- W2001525541 hasConcept C71924100 @default.
- W2001525541 hasConcept C98274493 @default.
- W2001525541 hasConceptScore W2001525541C111113717 @default.
- W2001525541 hasConceptScore W2001525541C112705442 @default.
- W2001525541 hasConceptScore W2001525541C126322002 @default.
- W2001525541 hasConceptScore W2001525541C170493617 @default.
- W2001525541 hasConceptScore W2001525541C203014093 @default.
- W2001525541 hasConceptScore W2001525541C2776804153 @default.
- W2001525541 hasConceptScore W2001525541C2778903070 @default.
- W2001525541 hasConceptScore W2001525541C2780372218 @default.
- W2001525541 hasConceptScore W2001525541C2780401358 @default.
- W2001525541 hasConceptScore W2001525541C59493245 @default.
- W2001525541 hasConceptScore W2001525541C71924100 @default.
- W2001525541 hasConceptScore W2001525541C98274493 @default.
- W2001525541 hasIssue "2" @default.
- W2001525541 hasLocation W20015255411 @default.
- W2001525541 hasLocation W20015255412 @default.
- W2001525541 hasOpenAccess W2001525541 @default.
- W2001525541 hasPrimaryLocation W20015255411 @default.
- W2001525541 hasRelatedWork W1980321510 @default.
- W2001525541 hasRelatedWork W2034583712 @default.
- W2001525541 hasRelatedWork W2073559455 @default.
- W2001525541 hasRelatedWork W2126743165 @default.
- W2001525541 hasRelatedWork W2131339985 @default.
- W2001525541 hasRelatedWork W2227061539 @default.
- W2001525541 hasRelatedWork W2470645353 @default.
- W2001525541 hasRelatedWork W2594910449 @default.
- W2001525541 hasRelatedWork W2898490955 @default.
- W2001525541 hasRelatedWork W2992709639 @default.
- W2001525541 hasVolume "33" @default.
- W2001525541 isParatext "false" @default.
- W2001525541 isRetracted "false" @default.
- W2001525541 magId "2001525541" @default.
- W2001525541 workType "article" @default.