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- W2001528041 abstract "The Wnt/β-catenin pathway and p53 are very common targets for genetic alterations in colorectal cancer, and relationships between them have been reported. Here, we describe the relation between Wnt/β-catenin signaling and the p53-related gene p73. p73, but not p53, activated a promoter containing the Tcf-binding sequence in Saos-2 cells, and the degree of activation was positively correlated with that on a p53-responsive promoter. Moreover, p73β enhanced Wnt/β-catenin signaling synergistically with Wnt-3a or exogenously expressed β-catenin, unlike p53, and the enhancement was not caused by the accumulation of β-catenin. These results show that the effects of p73 on Wnt/β-catenin signaling differ from those of p53." @default.
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- W2001528041 date "2001-05-01" @default.
- W2001528041 modified "2023-09-30" @default.
- W2001528041 title "p73β, a Variant of p73, Enhances Wnt/β-Catenin Signaling in Saos-2 Cells" @default.
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- W2001528041 doi "https://doi.org/10.1006/bbrc.2001.4788" @default.
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