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- W2001547608 abstract "Abstract DDD mice were fed 4, 2, or 0.5 g of d -penicillamine/kg of commercial diet from 3 weeks of age for periods ranging from 10 to 48 weeks. In male mice fed 4 g/kg diet, subcutaneous hemorrhage, dorsal hernia, priapism, and paralysis of the digits were observed. In a few mice, there was a ruptured aortic aneurysm. In most advanced cases, ataxia due to hindleg paralysis was observed. In male mice fed 2 g/kg diet, priapism and paralysis of the digits were noted at a lower incidence. No abnormalities were observed also in the mice fed 0.5 g/kg diet. Subcutaneous hemorrhage, dorsal hernia, and priapism were observed exclusively in males and orchidectomy significantly reduced the incidence. The incidence of digit paralysis, however, showed no sex difference and was not prevented by orchidectomy and administration of estrogen. Histologically, nerves, such as the optic and sciatic, showed moderate to marked demyelination and axonal degeneration, and spinal ganglion cells showed degenerative changes in mice fed the 4 g/kg diet. Back muscle covering the herniated area became thin or almost disappeared, and was replaced by a thin layer of collagenous tissue. When the onset of penicillamine feeding was delayed until 3 months of age, all the toxicities were remarkably reduced. Copper supplementation significantly prevented the toxicity while pyridoxine hydrochloride did not." @default.
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- W2001547608 title "d-Penicillamine toxicity in mice I. Pathological findings" @default.
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- W2001547608 doi "https://doi.org/10.1016/0041-008x(80)90094-0" @default.
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