Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001566685> ?p ?o ?g. }
- W2001566685 endingPage "5179" @default.
- W2001566685 startingPage "5171" @default.
- W2001566685 abstract "Abstract Aberrations of the Wnt canonical pathway (WCP) are known to contribute to the pathogenesis of various types of cancer. We hypothesize that these defects may exist in mantle cell lymphoma (MCL). Both the upstream and downstream aspects of WCP were examined in MCL cell lines and tumors. Using WCP-specific oligonucleotide arrays, we found that MCL highly and consistently expressed Wnt3 and Wnt10. β-catenin, a transcriptional factor that is a downstream target of WCP, is localized to the nucleus and transcriptionally active in all 3 MCL cell lines examined. By immunohistochemistry, 33 (52%) of 64 MCL tumors showed nuclear localization of β-catenin, which significantly correlated with the expression of the phosphorylated/inactive form of GSK3β (p-GSK3β; P = .011, Fisher). GSK3β inactivation is directly linked to WCP stimulation, since addition of recombinant sFRP proteins (a naturally occurring decoy for the Wnt receptors) resulted in a significant decrease in p-GSK3β. Down-regulation of DvL-2 (an upstream signaling protein in WCP) by siRNA or selective inhibition of β-catenin using quercetin significantly decreased cell growth in MCL cell lines. To conclude, WCP is constitutively activated in a subset of MCL and it appears to promote tumorigenesis in MCL." @default.
- W2001566685 created "2016-06-24" @default.
- W2001566685 creator A5001666207 @default.
- W2001566685 creator A5011827091 @default.
- W2001566685 creator A5049908569 @default.
- W2001566685 creator A5055846059 @default.
- W2001566685 creator A5068603411 @default.
- W2001566685 creator A5074497229 @default.
- W2001566685 creator A5077633685 @default.
- W2001566685 date "2008-12-15" @default.
- W2001566685 modified "2023-10-03" @default.
- W2001566685 title "Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma" @default.
- W2001566685 cites W1412788771 @default.
- W2001566685 cites W1529372075 @default.
- W2001566685 cites W1702807246 @default.
- W2001566685 cites W1973930630 @default.
- W2001566685 cites W1974083646 @default.
- W2001566685 cites W1976359234 @default.
- W2001566685 cites W1989620201 @default.
- W2001566685 cites W1990517558 @default.
- W2001566685 cites W1992166041 @default.
- W2001566685 cites W2005617503 @default.
- W2001566685 cites W2005852032 @default.
- W2001566685 cites W2011102246 @default.
- W2001566685 cites W2023192965 @default.
- W2001566685 cites W2024215200 @default.
- W2001566685 cites W2024997708 @default.
- W2001566685 cites W2025744983 @default.
- W2001566685 cites W2036242721 @default.
- W2001566685 cites W2041435092 @default.
- W2001566685 cites W2050933562 @default.
- W2001566685 cites W2056475871 @default.
- W2001566685 cites W2062096656 @default.
- W2001566685 cites W2070032004 @default.
- W2001566685 cites W2072209407 @default.
- W2001566685 cites W2072335762 @default.
- W2001566685 cites W2074605890 @default.
- W2001566685 cites W2097268699 @default.
- W2001566685 cites W2099801494 @default.
- W2001566685 cites W2106330601 @default.
- W2001566685 cites W2107648723 @default.
- W2001566685 cites W2116395753 @default.
- W2001566685 cites W2127893271 @default.
- W2001566685 cites W2146026996 @default.
- W2001566685 cites W2148584975 @default.
- W2001566685 cites W2164964874 @default.
- W2001566685 cites W2172092345 @default.
- W2001566685 cites W2408033184 @default.
- W2001566685 cites W2886180915 @default.
- W2001566685 cites W306697962 @default.
- W2001566685 cites W4241428578 @default.
- W2001566685 doi "https://doi.org/10.1182/blood-2008-02-139212" @default.
- W2001566685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2597612" @default.
- W2001566685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18787224" @default.
- W2001566685 hasPublicationYear "2008" @default.
- W2001566685 type Work @default.
- W2001566685 sameAs 2001566685 @default.
- W2001566685 citedByCount "81" @default.
- W2001566685 countsByYear W20015666852012 @default.
- W2001566685 countsByYear W20015666852013 @default.
- W2001566685 countsByYear W20015666852014 @default.
- W2001566685 countsByYear W20015666852015 @default.
- W2001566685 countsByYear W20015666852016 @default.
- W2001566685 countsByYear W20015666852017 @default.
- W2001566685 countsByYear W20015666852018 @default.
- W2001566685 countsByYear W20015666852019 @default.
- W2001566685 countsByYear W20015666852020 @default.
- W2001566685 countsByYear W20015666852021 @default.
- W2001566685 countsByYear W20015666852022 @default.
- W2001566685 countsByYear W20015666852023 @default.
- W2001566685 crossrefType "journal-article" @default.
- W2001566685 hasAuthorship W2001566685A5001666207 @default.
- W2001566685 hasAuthorship W2001566685A5011827091 @default.
- W2001566685 hasAuthorship W2001566685A5049908569 @default.
- W2001566685 hasAuthorship W2001566685A5055846059 @default.
- W2001566685 hasAuthorship W2001566685A5068603411 @default.
- W2001566685 hasAuthorship W2001566685A5074497229 @default.
- W2001566685 hasAuthorship W2001566685A5077633685 @default.
- W2001566685 hasBestOaLocation W20015666851 @default.
- W2001566685 hasConcept C104317684 @default.
- W2001566685 hasConcept C137620995 @default.
- W2001566685 hasConcept C1491633281 @default.
- W2001566685 hasConcept C153911025 @default.
- W2001566685 hasConcept C185592680 @default.
- W2001566685 hasConcept C203014093 @default.
- W2001566685 hasConcept C2777525834 @default.
- W2001566685 hasConcept C2779338263 @default.
- W2001566685 hasConcept C502942594 @default.
- W2001566685 hasConcept C54355233 @default.
- W2001566685 hasConcept C555283112 @default.
- W2001566685 hasConcept C62478195 @default.
- W2001566685 hasConcept C81885089 @default.
- W2001566685 hasConcept C86339819 @default.
- W2001566685 hasConcept C86803240 @default.
- W2001566685 hasConcept C95444343 @default.
- W2001566685 hasConceptScore W2001566685C104317684 @default.
- W2001566685 hasConceptScore W2001566685C137620995 @default.
- W2001566685 hasConceptScore W2001566685C1491633281 @default.