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• W2001567886 abstract "We report the safety, biodistribution, and internal radiation dosimetry of a new PET tracer, ¹⁸F-AH111585, a peptide with a high affinity for the α_vβ₃ integrin receptor involved in angiogenesis. <b>Methods:</b> PET scans of 8 healthy volunteers were acquired at time points up to 4 h after a bolus injection of ¹⁸F-AH111585. ¹⁸F activity in whole blood and plasma and excreted urine were measured up to 4 h after injection. In vivo ¹⁸F activities in up to 12 source regions were determined from quantitative analysis of the images. The cumulated activities subsequently calculated were then used to determine the internal radiation dosimetry, including the effective dose. <b>Results:</b> Injection of ¹⁸F-AH111585 was well tolerated in all subjects, with no serious or drug-related adverse events reported. The main route of ¹⁸F excretion was renal (37%), and the 3 highest initial uptakes were by liver (15%); combined walls of the small, upper large, and lower large intestines (11%); and kidneys (9%). The 3 highest absorbed doses were received by the urinary bladder wall (124 μGy/MBq), kidneys (102 μGy/MBq), and cardiac wall (59 μGy/MBq). The effective dose was 26 μGy/MBq. <b>Conclusion:</b>¹⁸F-AH111585 is a safe PET tracer with a dosimetry profile comparable to other common ¹⁸F PET tracers." @default.
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• W2001567886 date "2008-09-15" @default.
• W2001567886 modified "2023-09-25" @default.
• W2001567886 title "The Biodistribution and Radiation Dosimetry of the Arg-Gly-Asp Peptide ¹⁸F-AH111585 in Healthy Volunteers" @default.
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• W2001567886 doi "https://doi.org/10.2967/jnumed.108.052126" @default.
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