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- W2001569086 abstract "Human multidrug-resistant K562ADM cells showed 12-fold and 31-fold resistance to AZT (3′-azido-2′, 3′dideoxythymidine) and DDC (2′, 3′-dideoxycytidine), respectively. Other multidrug-resistant human cells CEMVLB100 and AdrRMCF-7 also showed resistance to these nucleoside analogs. However, verapamil (10μM) failed to reverse the resistance to the nucleoside analogs. Accumulation of [3H]AZT in human multidrug-resistant K562ADM, CEMVLB100 and AdrRMCF-7 cells decreased by 23, 35, and 42% respectively, as compared to their parental cells. These results suggest that anti-HIV nucleoside analogs including AZT, DDC could be transported by outward drug-transport system in the multidrug-resistant cells." @default.
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- W2001569086 date "1990-06-01" @default.
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- W2001569086 title "Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells" @default.
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- W2001569086 doi "https://doi.org/10.1016/0006-291x(90)91991-z" @default.
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