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- W2001569469 abstract "Apolipoprotein B100 (apoB) is a large amphipathic lipid-binding protein that is synthesized by hepatocytes and used to assemble and stabilize very low density lipoproteins (VLDL). It may have been derived through evolution from other lipid-associating proteins such as microsomal triglyceride transfer protein or vitellogenin. The correct folding of apoB requires assistance from chaperone proteins in co-translational lipidation, disulfide bond formation, and glycosylation. Any impairment in these processes results in co-translational targeting of the misfolded apoB molecule for proteasomal degradation. In fact, most of the regulation of apoB production is mediated by intracellular degradation. ApoB that misfolds post-translationally, perhaps as a result of oxidative stress, may be eliminated through autophagy. This review focuses on the proposed pentapartite domain structure of apoB, the role that each domain plays in the binding of lipid species and regulation of apoB synthesis, and the process of VLDL assembly. The factors involved in the recognition, ubiquitination, and proteasomal delivery of defective apoB molecules are also discussed." @default.
- W2001569469 created "2016-06-24" @default.
- W2001569469 creator A5022325715 @default.
- W2001569469 creator A5030295153 @default.
- W2001569469 creator A5070048406 @default.
- W2001569469 date "2010-04-01" @default.
- W2001569469 modified "2023-10-16" @default.
- W2001569469 title "Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process." @default.
- W2001569469 cites W1481795283 @default.
- W2001569469 cites W1503394109 @default.
- W2001569469 cites W1508733793 @default.
- W2001569469 cites W1524184984 @default.
- W2001569469 cites W1526141535 @default.
- W2001569469 cites W1544923804 @default.
- W2001569469 cites W1546570611 @default.
- W2001569469 cites W1563885314 @default.
- W2001569469 cites W1575864823 @default.
- W2001569469 cites W1598788587 @default.
- W2001569469 cites W1604339302 @default.
- W2001569469 cites W1817964822 @default.
- W2001569469 cites W1859156177 @default.
- W2001569469 cites W1964706050 @default.
- W2001569469 cites W1967358425 @default.
- W2001569469 cites W1968506143 @default.
- W2001569469 cites W1970719030 @default.
- W2001569469 cites W1972011521 @default.
- W2001569469 cites W1972638452 @default.
- W2001569469 cites W1975883167 @default.
- W2001569469 cites W1977941641 @default.
- W2001569469 cites W1979474533 @default.
- W2001569469 cites W1980093649 @default.
- W2001569469 cites W1980114424 @default.
- W2001569469 cites W1980376931 @default.
- W2001569469 cites W1982432510 @default.
- W2001569469 cites W1984474564 @default.
- W2001569469 cites W1985064032 @default.
- W2001569469 cites W1985176073 @default.
- W2001569469 cites W1986800491 @default.
- W2001569469 cites W1987537017 @default.
- W2001569469 cites W1988317051 @default.
- W2001569469 cites W1992604276 @default.
- W2001569469 cites W1992992449 @default.
- W2001569469 cites W1993099006 @default.
- W2001569469 cites W1997826161 @default.
- W2001569469 cites W1999233154 @default.
- W2001569469 cites W2001291386 @default.
- W2001569469 cites W2002892589 @default.
- W2001569469 cites W2004793722 @default.
- W2001569469 cites W2005174749 @default.
- W2001569469 cites W2007025936 @default.
- W2001569469 cites W2007770027 @default.
- W2001569469 cites W2009741382 @default.
- W2001569469 cites W2009997321 @default.
- W2001569469 cites W2010242022 @default.
- W2001569469 cites W2010862596 @default.
- W2001569469 cites W2012079242 @default.
- W2001569469 cites W2013339424 @default.
- W2001569469 cites W2014549284 @default.
- W2001569469 cites W2019377182 @default.
- W2001569469 cites W2019585786 @default.
- W2001569469 cites W2030031111 @default.
- W2001569469 cites W2031934153 @default.
- W2001569469 cites W2032486792 @default.
- W2001569469 cites W2033989333 @default.
- W2001569469 cites W2035094622 @default.
- W2001569469 cites W2035251713 @default.
- W2001569469 cites W2036420384 @default.
- W2001569469 cites W2038171923 @default.
- W2001569469 cites W2039890032 @default.
- W2001569469 cites W2045549815 @default.
- W2001569469 cites W2046959088 @default.
- W2001569469 cites W2049881558 @default.
- W2001569469 cites W2049930242 @default.
- W2001569469 cites W2050994990 @default.
- W2001569469 cites W2051528563 @default.
- W2001569469 cites W2052430651 @default.
- W2001569469 cites W2053500970 @default.
- W2001569469 cites W2055069386 @default.
- W2001569469 cites W2058588045 @default.
- W2001569469 cites W2060341713 @default.
- W2001569469 cites W2062115941 @default.
- W2001569469 cites W2064079079 @default.
- W2001569469 cites W2065478879 @default.
- W2001569469 cites W2065656920 @default.
- W2001569469 cites W2065689560 @default.
- W2001569469 cites W2066538173 @default.
- W2001569469 cites W2067406978 @default.
- W2001569469 cites W2067911054 @default.
- W2001569469 cites W2069663235 @default.
- W2001569469 cites W2070288904 @default.
- W2001569469 cites W2071457248 @default.
- W2001569469 cites W2074394032 @default.
- W2001569469 cites W2074937090 @default.
- W2001569469 cites W2078067541 @default.
- W2001569469 cites W2079261384 @default.
- W2001569469 cites W2079653456 @default.
- W2001569469 cites W2081249929 @default.
- W2001569469 cites W2082542914 @default.