FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001569479> ?p ?o ?g. }

• W2001569479 endingPage "466" @default.
• W2001569479 startingPage "461" @default.
• W2001569479 abstract "The pattern of failure of low grade gliomas following radiotherapy is less well known than that of the high grade gliomas. Stereotactic histologic studies have suggested that tumor cells extend beyond imaging abnormalities, and that large margins would be required for radiotherapy target volumes to encompass all of the neoplasm. Our experience using computerized tomography (CT)- and magnetic resonance (MR)-planned irradiation of low grade gliomas was reviewed to determine the pattern of tumor recurrence, in an effort to clinically define the minimum margin required.Forty-six patients with low grade supratentorial gliomas were treated between April 1985 and November 1992 using three-dimensional (3D) conformal CT- or MR-planned external beam radiotherapy. Fields were designed to encompass a target volume created by adding a margin to the tumor in three dimensions. Generally, patients were treated using shrinking fields with an initial target (tumor plus a 1 to 3 cm margin) treated to a dose of 45 to 50.4 (median 50.4) Gy, and a boost (tumor plus a 0 to 2 cm margin) treated to a total of 54 to 59.4 (median 59.4) Gy. Median follow-up was 32.9 months.There have been 11 failures; all of these occurred within the radiographic abnormality (either T2 prolongation or CT hypodensity) visualized at the time of treatment planning (i.e., all failures were within the boost volume). Median time to failure was 53 months. Because all failures were local, there was no relationship between the amount by which the tumor volumes were expanded to create target volumes and the eventual outcome.Despite pathologic data suggesting that low grade glioma cells can be found outside the MR T2-signal abnormality in many cases, our results demonstrate that conformal external beam radiotherapy, in which the high dose volume is limited, does not result in increased marginal or out-of-field failures. Until control of tumor within the radiographically abnormal volume can be achieved, the need for large fields to treat prophylactically microscopic disease beyond the visualized tumor volume is questionable. The use of conformal fields might be associated with reduced toxicity, and thereby allow delivery of higher total doses to the central tumor." @default.
• W2001569479 created "2016-06-24" @default.
• W2001569479 creator A5020221189 @default.
• W2001569479 creator A5030018523 @default.
• W2001569479 creator A5034370633 @default.
• W2001569479 creator A5045067253 @default.
• W2001569479 creator A5045162411 @default.
• W2001569479 creator A5048649057 @default.
• W2001569479 creator A5070163800 @default.
• W2001569479 creator A5081534846 @default.
• W2001569479 date "1995-02-01" @default.
• W2001569479 modified "2023-09-27" @default.
• W2001569479 title "Low grade gliomas: Preliminary analysis of failure patterns among patients treated using 3D conformal external beam irradiation" @default.
• W2001569479 cites W1964421702 @default.
• W2001569479 cites W1967734901 @default.
• W2001569479 cites W1972512104 @default.
• W2001569479 cites W1972532120 @default.
• W2001569479 cites W1982182795 @default.
• W2001569479 cites W1990616299 @default.
• W2001569479 cites W2031720250 @default.
• W2001569479 cites W2036560693 @default.
• W2001569479 cites W2041212687 @default.
• W2001569479 cites W2050397987 @default.
• W2001569479 cites W2054827039 @default.
• W2001569479 cites W2063106486 @default.
• W2001569479 cites W2073005838 @default.
• W2001569479 cites W2079618669 @default.
• W2001569479 cites W2088454377 @default.
• W2001569479 cites W2102628178 @default.
• W2001569479 cites W2109937583 @default.
• W2001569479 cites W2113012900 @default.
• W2001569479 cites W2127180535 @default.
• W2001569479 cites W2154218549 @default.
• W2001569479 cites W2168934883 @default.
• W2001569479 cites W4323874164 @default.
• W2001569479 doi "https://doi.org/10.1016/0360-3016(94)00400-f" @default.
• W2001569479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7852107" @default.
• W2001569479 hasPublicationYear "1995" @default.
• W2001569479 type Work @default.
• W2001569479 sameAs 2001569479 @default.
• W2001569479 citedByCount "46" @default.
• W2001569479 countsByYear W20015694792015 @default.
• W2001569479 countsByYear W20015694792017 @default.
• W2001569479 countsByYear W20015694792018 @default.
• W2001569479 countsByYear W20015694792019 @default.
• W2001569479 countsByYear W20015694792020 @default.
• W2001569479 countsByYear W20015694792021 @default.
• W2001569479 crossrefType "journal-article" @default.
• W2001569479 hasAuthorship W2001569479A5020221189 @default.
• W2001569479 hasAuthorship W2001569479A5030018523 @default.
• W2001569479 hasAuthorship W2001569479A5034370633 @default.
• W2001569479 hasAuthorship W2001569479A5045067253 @default.
• W2001569479 hasAuthorship W2001569479A5045162411 @default.
• W2001569479 hasAuthorship W2001569479A5048649057 @default.
• W2001569479 hasAuthorship W2001569479A5070163800 @default.
• W2001569479 hasAuthorship W2001569479A5081534846 @default.
• W2001569479 hasConcept C119857082 @default.
• W2001569479 hasConcept C126838900 @default.
• W2001569479 hasConcept C143409427 @default.
• W2001569479 hasConcept C201645570 @default.
• W2001569479 hasConcept C2775908122 @default.
• W2001569479 hasConcept C2777416452 @default.
• W2001569479 hasConcept C2778227246 @default.
• W2001569479 hasConcept C2989005 @default.
• W2001569479 hasConcept C41008148 @default.
• W2001569479 hasConcept C502942594 @default.
• W2001569479 hasConcept C509974204 @default.
• W2001569479 hasConcept C71924100 @default.
• W2001569479 hasConcept C774472 @default.
• W2001569479 hasConceptScore W2001569479C119857082 @default.
• W2001569479 hasConceptScore W2001569479C126838900 @default.
• W2001569479 hasConceptScore W2001569479C143409427 @default.
• W2001569479 hasConceptScore W2001569479C201645570 @default.
• W2001569479 hasConceptScore W2001569479C2775908122 @default.
• W2001569479 hasConceptScore W2001569479C2777416452 @default.
• W2001569479 hasConceptScore W2001569479C2778227246 @default.
• W2001569479 hasConceptScore W2001569479C2989005 @default.
• W2001569479 hasConceptScore W2001569479C41008148 @default.
• W2001569479 hasConceptScore W2001569479C502942594 @default.
• W2001569479 hasConceptScore W2001569479C509974204 @default.
• W2001569479 hasConceptScore W2001569479C71924100 @default.
• W2001569479 hasConceptScore W2001569479C774472 @default.
• W2001569479 hasIssue "3" @default.
• W2001569479 hasLocation W20015694791 @default.
• W2001569479 hasLocation W20015694792 @default.
• W2001569479 hasOpenAccess W2001569479 @default.
• W2001569479 hasPrimaryLocation W20015694791 @default.
• W2001569479 hasRelatedWork W1965188844 @default.
• W2001569479 hasRelatedWork W2007234908 @default.
• W2001569479 hasRelatedWork W2059150988 @default.
• W2001569479 hasRelatedWork W2090353684 @default.
• W2001569479 hasRelatedWork W2363834598 @default.
• W2001569479 hasRelatedWork W2410925255 @default.
• W2001569479 hasRelatedWork W2513479736 @default.
• W2001569479 hasRelatedWork W3094186661 @default.
• W2001569479 hasRelatedWork W4243045879 @default.
• W2001569479 hasRelatedWork W4283587651 @default.
• W2001569479 hasVolume "31" @default.

• next