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- W2001569787 abstract "Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to evaluate antiviral activity. A compound with a three-carbon linker chain connecting two dioxane moieties inhibited virus production by 50% at a concentration of 40 μM, while (R)-hydroxymethyldioxane inhibited virus production by 50% at a concentration of 1 μM. Both compounds were not cytotoxic in uninfected BHK cells at concentrations of 1 mM." @default.
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- W2001569787 date "2005-07-01" @default.
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- W2001569787 title "Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein" @default.
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- W2001569787 doi "https://doi.org/10.1016/j.bmcl.2005.05.013" @default.
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