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• W2001570214 abstract "Objective. Interleukin-10 (IL-10) is a potent inhibitor of the proinflammatory cytokines, including tumor necrosis factor α and IL-1, which are considered important in the pathogenesis of rheumatoid arthritis (RA). The study was undertaken to establish whether IL-10 can ameliorate arthritis in the collagen-induced arthritis (CIA) model of RA. Methods. DBA/1 mice were immunized with bovine type II collagen in adjuvant, and treated daily after disease onset with recombinant murine IL-10 or with saline as a control. Mice were monitored for paw swelling and clinical score. Histologic analysis was also performed. Results. IL-10 treatment of established CIA inhibited paw swelling (P < 0.0001), as well as disease progression as defined by clinical score (P < 0.0002). Cartilage destruction, as assessed histologically, was reduced in IL-10–treated mice compared with controls (P < 0.01). Conclusion. IL-10 suppresses established CIA, probably by inhibiting proinflammatory cytokine production. Our results, taken together with previously reported findings, indicate a potential therapeutic role for IL-10 in RA." @default.
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• W2001570214 date "1996-03-01" @default.
• W2001570214 modified "2023-09-26" @default.
• W2001570214 title "Interleukin-10 inhibition of the progression of established collagen-induced arthritis" @default.
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• W2001570214 doi "https://doi.org/10.1002/art.1780390318" @default.
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