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• W2001570312 abstract "During last decades a considerable attempt has been made to prevent cardiovascular disease (CVD). Nevertheless, CVD remains a leading cause of death world wide [1]. The guidelines of medical scientific societies for primary and secondary prevention of CVD are directed towards established CVD risk factors (dyslipidemia, diabetes mellitus, hypertension, obesity, smoking and others). As far as dyslipidemia is concerned, the first priority, according to the guidelines [2], is to achieve optimal low density lipoprotein cholesterol (LDL-C) levels. Many clinical trials have shown that hypolipidemic treatment besides lowering LDL-C also significantly reduces CVD-related morbidity and mortality [3, 4]. Nevertheless, a considerable number of treated subjects still have CVD events. Thus, the need for additional therapeutic treatment such as increasing high density lipoprotein cholesterol (HDL-C) levels and decreasing levels of triglycerides (TG) has been suggested [5]. In this context, torcetrapib, an inhibitor of cholesteryl ester transport protein (CETP), increased HDL-C levels and decreased LDL-C levels [6-8]. However, the drug was withdrawn due to side effects." @default.
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• W2001570312 date "2009-06-11" @default.
• W2001570312 modified "2023-09-26" @default.
• W2001570312 title "The Link Between Human and Transgenic Animal Studies Involving Postprandial Hypertriglyceridemia and CETP Gene Polymorphisms" @default.
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• W2001570312 doi "https://doi.org/10.2174/1874192400903010048" @default.
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