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• W2001574956 abstract "Abstract Runt‐related transcription factor 3 ( RUNX 3) is a putative tumour suppressor via regulating the expression of a series of target genes. Clinical studies demonstrated that loss of RUNX 3 expression is associated with gastric cancer progression and poor prognosis, but the underlying mechanism is not entirely clear. Accumulating evidence shows that the epithelial–mesenchymal transition ( EMT ) plays an important role in cancer relapse and metastasis. Therefore, we addressed whether RUNX 3 has a role in the EMT in gastric cancer. Knockdown of RUNX 3 promoted cell invasion and increased the protein expression of the mesenchymal marker vimentin in human gastric cancer cells. Overexpression of RUNX 3 suppressed cell invasion and decreased the protein expression of vimentin in the cells and inhibited gastric cancer cells colonization in nude mice. Furthermore, overexpression of RUNX 3 increased the expression of micro RNA ‐30a (miR‐30a), and miR‐30a directly targeted the 3′ untranslated region of vimentin and decreased its protein level. miR‐30a inhibitor abrogated RUNX 3‐mediated inhibition of cell invasion and downregulation of vimentin. Thus, RUNX 3 suppressed gastric cancer cell invasion and vimentin expression by activating miR‐30a. In gastric cancer patients, levels of RUNX 3 were positively correlated with miR‐30a and negatively associated with the levels of vimentin. Collectively, our data suggest a novel molecular mechanism for the tumour suppressor activity of RUNX 3. Effective therapy targeting the RUNX 3 pathway may help control gastric cancer cell invasion and metastasis by inhibiting the EMT ." @default.
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• W2001574956 date "2014-01-22" @default.
• W2001574956 modified "2023-10-03" @default.
• W2001574956 title "<scp>RUNX</scp> 3 regulates vimentin expression <i>via</i> miR‐30a during epithelial–mesenchymal transition in gastric cancer cells" @default.
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• W2001574956 doi "https://doi.org/10.1111/jcmm.12209" @default.
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