Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001580765> ?p ?o ?g. }
- W2001580765 endingPage "444" @default.
- W2001580765 startingPage "437" @default.
- W2001580765 abstract "The development of the technological armamentarium of molecular biology has revolutionized biomedical research in general and nephrologic investigation in particular. In addition to the recent identification of several genes involved in normal kidney function and pathologic conditions, our knowledge regarding the role of cytokines in primary renal diseases, transplant rejection, and dialysis effects has expanded greatly. In particular, molecular biologic methodology has provided insight into the mechanisms controlling cytokine gene regulation, which occurs primarily at the transcriptional level and is mediated by DNA-binding proteins interacting with specific recognition motifs in genetic promoter and enhancer elements. Interleukin-6 (IL-6) is discussed as an example because it is a secretory product of mesangial cells and participates in the cytokine network that determines glomerular and interstitial inflammation. In our analysis of IL-6 gene regulation employing reporter gene and electrophoretic mobility shift assays, we have found that bacterial lipopolysaccharide and cyclic adenosine monophosphate synergistically induce IL-6 expression in macrophages through at least four transcription factors, including AP-1, cAMP-responsive element-binding protein (CREB), NF-IL6, and NF-kappa B. One of the most exciting areas of future research will focus on transcription factor activation in experimental and clinical disease states. Novel therapeutic approaches targeting transcriptional regulation are currently being explored." @default.
- W2001580765 created "2016-06-24" @default.
- W2001580765 creator A5014386892 @default.
- W2001580765 date "1996-06-01" @default.
- W2001580765 modified "2023-10-14" @default.
- W2001580765 title "Molecular Biology of Cytokines" @default.
- W2001580765 cites W128911665 @default.
- W2001580765 cites W1491336114 @default.
- W2001580765 cites W1523923158 @default.
- W2001580765 cites W1560572144 @default.
- W2001580765 cites W1601384284 @default.
- W2001580765 cites W1647832452 @default.
- W2001580765 cites W1766651653 @default.
- W2001580765 cites W179818011 @default.
- W2001580765 cites W1838497045 @default.
- W2001580765 cites W1895052772 @default.
- W2001580765 cites W1931481640 @default.
- W2001580765 cites W1966243688 @default.
- W2001580765 cites W1966613111 @default.
- W2001580765 cites W1968005732 @default.
- W2001580765 cites W1969456730 @default.
- W2001580765 cites W1973135307 @default.
- W2001580765 cites W1976275735 @default.
- W2001580765 cites W1977013336 @default.
- W2001580765 cites W1982062664 @default.
- W2001580765 cites W1987175676 @default.
- W2001580765 cites W1987517079 @default.
- W2001580765 cites W1992294787 @default.
- W2001580765 cites W2001534082 @default.
- W2001580765 cites W2002462895 @default.
- W2001580765 cites W2006239014 @default.
- W2001580765 cites W2010237936 @default.
- W2001580765 cites W2010372266 @default.
- W2001580765 cites W2013215719 @default.
- W2001580765 cites W2013817592 @default.
- W2001580765 cites W2014668735 @default.
- W2001580765 cites W2028242823 @default.
- W2001580765 cites W2030254556 @default.
- W2001580765 cites W2033020230 @default.
- W2001580765 cites W2033810895 @default.
- W2001580765 cites W2035616122 @default.
- W2001580765 cites W2037262370 @default.
- W2001580765 cites W2043123463 @default.
- W2001580765 cites W2044815138 @default.
- W2001580765 cites W2060559383 @default.
- W2001580765 cites W2060912271 @default.
- W2001580765 cites W2067780050 @default.
- W2001580765 cites W2068742363 @default.
- W2001580765 cites W2073993982 @default.
- W2001580765 cites W2082301173 @default.
- W2001580765 cites W2082791667 @default.
- W2001580765 cites W2084519792 @default.
- W2001580765 cites W2085210314 @default.
- W2001580765 cites W2089272736 @default.
- W2001580765 cites W2089478514 @default.
- W2001580765 cites W2092598484 @default.
- W2001580765 cites W2094664478 @default.
- W2001580765 cites W2096031993 @default.
- W2001580765 cites W2108544093 @default.
- W2001580765 cites W2112941906 @default.
- W2001580765 cites W2133982451 @default.
- W2001580765 cites W2134521609 @default.
- W2001580765 cites W2140552959 @default.
- W2001580765 cites W2141350812 @default.
- W2001580765 cites W2162141496 @default.
- W2001580765 cites W2168889062 @default.
- W2001580765 cites W2171916504 @default.
- W2001580765 cites W2345643226 @default.
- W2001580765 cites W2415112483 @default.
- W2001580765 cites W2474734983 @default.
- W2001580765 cites W321874077 @default.
- W2001580765 cites W4230001666 @default.
- W2001580765 cites W4230897685 @default.
- W2001580765 cites W4240074687 @default.
- W2001580765 cites W4254175844 @default.
- W2001580765 cites W4322388302 @default.
- W2001580765 doi "https://doi.org/10.1111/j.1525-1594.1996.tb04529.x" @default.
- W2001580765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8725624" @default.
- W2001580765 hasPublicationYear "1996" @default.
- W2001580765 type Work @default.
- W2001580765 sameAs 2001580765 @default.
- W2001580765 citedByCount "42" @default.
- W2001580765 countsByYear W20015807652012 @default.
- W2001580765 countsByYear W20015807652013 @default.
- W2001580765 countsByYear W20015807652015 @default.
- W2001580765 countsByYear W20015807652018 @default.
- W2001580765 countsByYear W20015807652020 @default.
- W2001580765 countsByYear W20015807652021 @default.
- W2001580765 countsByYear W20015807652022 @default.
- W2001580765 countsByYear W20015807652023 @default.
- W2001580765 crossrefType "journal-article" @default.
- W2001580765 hasAuthorship W2001580765A5014386892 @default.
- W2001580765 hasConcept C104317684 @default.
- W2001580765 hasConcept C111936080 @default.
- W2001580765 hasConcept C150194340 @default.
- W2001580765 hasConcept C1629964 @default.
- W2001580765 hasConcept C165864922 @default.
- W2001580765 hasConcept C203014093 @default.