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- W2001593340 startingPage "e1002122" @default.
- W2001593340 abstract "The fusion of two distinct prominences into one continuous structure is common during development and typically requires integration of two epithelia and subsequent removal of that intervening epithelium. Using confocal live imaging, we directly observed the cellular processes underlying tissue fusion, using the secondary palatal shelves as a model. We find that convergence of a multi-layered epithelium into a single-layer epithelium is an essential early step, driven by cell intercalation, and is concurrent to orthogonal cell displacement and epithelial cell extrusion. Functional studies in mice indicate that this process requires an actomyosin contractility pathway involving Rho kinase (ROCK) and myosin light chain kinase (MLCK), culminating in the activation of non-muscle myosin IIA (NMIIA). Together, these data indicate that actomyosin contractility drives cell intercalation and cell extrusion during palate fusion and suggest a general mechanism for tissue fusion in development." @default.
- W2001593340 created "2016-06-24" @default.
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- W2001593340 date "2015-04-07" @default.
- W2001593340 modified "2023-10-14" @default.
- W2001593340 title "Convergence and Extrusion Are Required for Normal Fusion of the Mammalian Secondary Palate" @default.
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- W2001593340 doi "https://doi.org/10.1371/journal.pbio.1002122" @default.
- W2001593340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4388528" @default.
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