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• W2001597908 abstract "The presence of biomarkers in the cerebrospinal fluid (CSF) is indispensable for an accurate differential diagnosis of neurodegenerative disorders. Besides the presence of astrocytosis in most neurodegenerative disorders, high levels of the astrocyte-secreted glial fibrillar acidic protein (GFAP) in CSF of patients with Alzheimer's disease (AD) has also been reported. On the other hand, the presence of GFAP in CSF has not been fully investigated in other disorders causing dementia, such as dementia with Lewy bodies (DLB) and frontotemporal lobar degeneration (FTLD). In this study, we determined GFAP levels in CSF of healthy control (HC), AD, DLB, and FTLD patients to address two questions: (i) Do GFAP levels differ among these disorders? and (ii) Can GFAP be used as a biomarker for the differential diagnosis of these neurodegenerative disorders? HC (n = 15), AD (n = 16), DLB (n = 16), and FTLD (n = 15) subjects were recruited at Tohoku University Hospital. CSF samples were obtained from each fasted subject. The presence of GFAP in CSF was examined using a sandwich ELISA system (BioVendor Research and Diagnostic Product, Brno, Czech Republic). The study protocol was approved by the Committee on Clinical Investigation at Tohoku University School of Medicine. After a complete description of the study to the patients and subjects, written informed consent was obtained. obt ained. Ages were not significantly different among the four groups. Additionally, mini-mental state examination (MMSE) scores, as a scale of dementia progression, did not show significant difference among these groups. GFAP levels in CSF were quantified in the subjects from the HC, AD, DLB, and FTLD groups. GFAP levels in the AD, DLB, and FTLD patients were significantly higher than those in the HC subjects. Although GFAP levels were not significantly different between the AD and DLB patients, a higher GFAP level was observed in the FTLD patients than in the AD and DLB patients. These differences of GFAP in CSF still remained following multivariate regression analysis to adjust for age and gender differences. Representative neurological disorders causing dementia showed higher GFAP levels in CSF. GFAP levels in CSF of FTLD patients were the highest among all these disorders, indicating the high clinical progression rate of FTLD compared with that of AD and DLB." @default.
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• W2001597908 date "2014-07-01" @default.
• W2001597908 modified "2023-10-16" @default.
• W2001597908 title "P1-138: GFAP IN THE CEREBROSPINAL FLUID OF AD, DLB, AND FTLD" @default.
• W2001597908 doi "https://doi.org/10.1016/j.jalz.2014.05.375" @default.
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