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- W2001617346 abstract "<h3>Background</h3> Approximately 20% to 50% of patients are not adherent to medical therapy. This review was performed to summarize, categorize, and estimate the effect size (ES) of interventions to improve medication adherence in chronic medical conditions. <h3>Methods</h3> Randomized controlled trials published from January 1967 to September 2004 were eligible if they described 1 or more unconfounded interventions intended to enhance adherence with self-administered medications in the treatment of chronic medical conditions. Trials that reported at least 1 measure of medication adherence and 1 clinical outcome, with at least 80% follow-up during 6 months, were included. Study characteristics and results for adherence and clinical outcomes were extracted. In addition, ES was calculated for each outcome. <h3>Results</h3> Among 37 eligible trials (including 12 informational, 10 behavioral, and 15 combined informational, behavioral, and/or social investigations), 20 studies reported a significant improvement in at least 1 adherence measure. Adherence increased most consistently with behavioral interventions that reduced dosing demands (3 of 3 studies, large ES [0.89-1.20]) and those involving monitoring and feedback (3 of 4 studies, small to large ES [0.27-0.81]). Adherence also improved in 6 multisession informational trials (small to large ES [0.35-1.13]) and 8 combined interventions (small to large ES [absolute value, 0.43-1.20]). Eleven studies (4 informational, 3 behavioral, and 4 combined) demonstrated improvement in at least 1 clinical outcome, but effects were variable (very small to large ES [0.17-3.41]) and not consistently related to changes in adherence. <h3>Conclusion</h3> Several types of interventions are effective in improving medication adherence in chronic medical conditions, but few significantly affected clinical outcomes." @default.
- W2001617346 created "2016-06-24" @default.
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- W2001617346 date "2007-03-26" @default.
- W2001617346 modified "2023-10-11" @default.
- W2001617346 title "Interventions to Enhance Medication Adherence in Chronic Medical Conditions" @default.
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- W2001617346 doi "https://doi.org/10.1001/archinte.167.6.540" @default.
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