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- W2001621485 abstract "FORMERLY untouchable human joints are now receiving the attention of workers in widely separated fields. This is not surprising for there has been a growing realization that in the synovial joint, biochemistry, anatomy and mechanics converge and influence each other in many direct and intimate ways. A movable joint is composed of the synovial membrane and capsule, articular cartilage and subchondral bone, ligaments, tendons and fibrocartilages, and synovial fluid. The most urgent need has been a means to obtain specimens of these joint components from living subjects. This need was perhaps first met by the introduction of safe and effective needles [24] that permitted biopsies of synovial membrane from closed joints of ambulatory patients. Specimens of synovial membrane, cartilage, or bone are now obtained with increasing frequency by orthopedic surgeons during arthrotomy [5, 61, or from amputated limbs [7]. A great deal of information is accumulating from studies on joint components using techniques of chemistry, immunology, histology, cytochemistry, electron microscopy, and immunohistology. Integration and synthesis of this information into a coherent view of joint function is making progress, especially in the normal joint [8, 91. New studies and ideas relate the structure and metabolism of the synovial membrane to its secretion of synovial fluid, and explore the function of this viscous fluid as a nutrient source and lubricant for the moving articular cartilages. This paper will concentrate on some aspects of the altered structure and function of synovial joints involved by rheumatoid arthritis." @default.
- W2001621485 created "2016-06-24" @default.
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- W2001621485 date "1963-08-01" @default.
- W2001621485 modified "2023-10-06" @default.
- W2001621485 title "Biochemical events in joint disease" @default.
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- W2001621485 doi "https://doi.org/10.1016/0021-9681(63)90134-6" @default.
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