Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001631043> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2001631043 endingPage "120" @default.
- W2001631043 startingPage "115" @default.
- W2001631043 abstract "We evaluated the cytotoxicity of antiglaucoma ophthalmic solutions preserved with the same concentration of benzalkonium chloride (BAK) in four cultured corneal and conjunctival cell lines. The viability of cell cultures was determined following the exposure of cells to timolol maleate, dorzolamide, and their fixed combination, Kosoputo® (MSD, a Japanese formulation of Cosopt® (Merck) ) , and two commercially available eyedrop solutions, 0.5% Timpotol® (containing 0.5% timolol maleate, MSD) and 1% Trusopt® (containing 1% dorzolamide, MSD) for varying exposure times and at various dilutions using the MTT and neutral red assays. All the three commercially available eyedrop solutions tested in this study were preserved with 0.005% BAK. The toxicity of each solution was compared using the % cell viability score (CVS) . Cell viability was also subjected to statistical analysis using ANOVA, Dunnett's multiple comparison tests and a chi-square test. %CVS50/%CVS40/80s for the tested solutions were 53/-13 for 0.5% Timoptol®, 100/88 for preservative-free 0.5% timolol maleate, 50/ -10 for 1% Trusopt®, 72/100 for preservative-free 1% dorzolamide, and 44/ -17 for Kosoputo®. The results of statistical analysis were consistent to them. In conclusion, Kosoputo® had greater cytotoxicity than each component; however, in actual use it may have the advantages of reduced toxicity (side effect) due to reduced instillation frequency, and better patient adherence to the treatment regimen as well as a comparable pressure reduction effect." @default.
- W2001631043 created "2016-06-24" @default.
- W2001631043 creator A5036074756 @default.
- W2001631043 creator A5058491023 @default.
- W2001631043 creator A5075048789 @default.
- W2001631043 date "2012-01-01" @default.
- W2001631043 modified "2023-09-25" @default.
- W2001631043 title "Comparative Study of In Vitro Ocular Surface Cytotoxicity of a Fixed Combination of 0.5% Timolol/1% Dorzolamide Eyedrop and Its Components with 0.005% Benzalkonium Chloride" @default.
- W2001631043 cites W1987172167 @default.
- W2001631043 cites W1996428350 @default.
- W2001631043 cites W2009259670 @default.
- W2001631043 cites W2013383108 @default.
- W2001631043 cites W2064280255 @default.
- W2001631043 cites W2068119665 @default.
- W2001631043 cites W2080276945 @default.
- W2001631043 cites W2081994851 @default.
- W2001631043 cites W2089139160 @default.
- W2001631043 cites W2091063199 @default.
- W2001631043 cites W2101994642 @default.
- W2001631043 doi "https://doi.org/10.4265/bio.17.115" @default.
- W2001631043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23007102" @default.
- W2001631043 hasPublicationYear "2012" @default.
- W2001631043 type Work @default.
- W2001631043 sameAs 2001631043 @default.
- W2001631043 citedByCount "4" @default.
- W2001631043 countsByYear W20016310432014 @default.
- W2001631043 countsByYear W20016310432016 @default.
- W2001631043 countsByYear W20016310432022 @default.
- W2001631043 countsByYear W20016310432023 @default.
- W2001631043 crossrefType "journal-article" @default.
- W2001631043 hasAuthorship W2001631043A5036074756 @default.
- W2001631043 hasAuthorship W2001631043A5058491023 @default.
- W2001631043 hasAuthorship W2001631043A5075048789 @default.
- W2001631043 hasBestOaLocation W20016310431 @default.
- W2001631043 hasConcept C109316439 @default.
- W2001631043 hasConcept C118487528 @default.
- W2001631043 hasConcept C178790620 @default.
- W2001631043 hasConcept C185592680 @default.
- W2001631043 hasConcept C202751555 @default.
- W2001631043 hasConcept C2775919038 @default.
- W2001631043 hasConcept C2776727336 @default.
- W2001631043 hasConcept C2778073030 @default.
- W2001631043 hasConcept C2780484033 @default.
- W2001631043 hasConcept C2781092963 @default.
- W2001631043 hasConcept C29730261 @default.
- W2001631043 hasConcept C43617362 @default.
- W2001631043 hasConcept C55493867 @default.
- W2001631043 hasConcept C67031304 @default.
- W2001631043 hasConcept C71924100 @default.
- W2001631043 hasConcept C98274493 @default.
- W2001631043 hasConceptScore W2001631043C109316439 @default.
- W2001631043 hasConceptScore W2001631043C118487528 @default.
- W2001631043 hasConceptScore W2001631043C178790620 @default.
- W2001631043 hasConceptScore W2001631043C185592680 @default.
- W2001631043 hasConceptScore W2001631043C202751555 @default.
- W2001631043 hasConceptScore W2001631043C2775919038 @default.
- W2001631043 hasConceptScore W2001631043C2776727336 @default.
- W2001631043 hasConceptScore W2001631043C2778073030 @default.
- W2001631043 hasConceptScore W2001631043C2780484033 @default.
- W2001631043 hasConceptScore W2001631043C2781092963 @default.
- W2001631043 hasConceptScore W2001631043C29730261 @default.
- W2001631043 hasConceptScore W2001631043C43617362 @default.
- W2001631043 hasConceptScore W2001631043C55493867 @default.
- W2001631043 hasConceptScore W2001631043C67031304 @default.
- W2001631043 hasConceptScore W2001631043C71924100 @default.
- W2001631043 hasConceptScore W2001631043C98274493 @default.
- W2001631043 hasIssue "3" @default.
- W2001631043 hasLocation W20016310431 @default.
- W2001631043 hasLocation W20016310432 @default.
- W2001631043 hasOpenAccess W2001631043 @default.
- W2001631043 hasPrimaryLocation W20016310431 @default.
- W2001631043 hasRelatedWork W1987172167 @default.
- W2001631043 hasRelatedWork W1989439506 @default.
- W2001631043 hasRelatedWork W2001631043 @default.
- W2001631043 hasRelatedWork W2060295704 @default.
- W2001631043 hasRelatedWork W2155396062 @default.
- W2001631043 hasRelatedWork W2768372406 @default.
- W2001631043 hasRelatedWork W3037975320 @default.
- W2001631043 hasRelatedWork W3119585194 @default.
- W2001631043 hasRelatedWork W3204721845 @default.
- W2001631043 hasRelatedWork W4380627932 @default.
- W2001631043 hasVolume "17" @default.
- W2001631043 isParatext "false" @default.
- W2001631043 isRetracted "false" @default.
- W2001631043 magId "2001631043" @default.
- W2001631043 workType "article" @default.