FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001632704> ?p ?o ?g. }

• W2001632704 endingPage "73" @default.
• W2001632704 startingPage "65" @default.
• W2001632704 abstract "CD306, also known as soluble leukocyte-associated immunoglobulin-like receptor-2 (LAIR-2), is a member of an immunoglobulin superfamily with the shared characteristic of an immunoglobulin-like C2-type domain. CD306 is speculated to be secretory and has 84% similarity with the extracellular domain of CD305, which binds to the same ligands as CD306. However, data on its distribution are absent due to the lack of an efficient method to detect it. In this study, we successfully cloned the cDNA of CD306 from the peripheral blood mononuclear cells (PBMCs) of patients with hemorrhagic fever with renal syndrome. The fusion proteins were expressed and purified, and three strains of monoclonal antibodies (mAbs) against CD306 were prepared and characterized. The sandwich ELISA for detecting CD306 was established and optimized with sensitivity up to 15 pg/ml, and the assay showed high specificity for the detection of CD306. With this method, a right skewed frequency distribution of CD306 in the sera of healthy subjects was determined. The concentrations of CD306 in sera and urine were detected in patients with different diseases. Aberrantly high levels of CD306 were found in the sera of pregnant women and patients with inflammation and rheumatic heart disease and in the urine of pregnant women. Meanwhile, there was a positive correlation between CD306 and soluble CD305 expression and secretion levels in sera and urine samples from patients, and both proteins inhibited CD305-mediated immunosuppressive functions. Our results demonstrate that CD306 represents a potentially useful predictor for disease diagnosis and that the method developed has potential for clinical application." @default.
• W2001632704 created "2016-06-24" @default.
• W2001632704 creator A5006088751 @default.
• W2001632704 creator A5006822602 @default.
• W2001632704 creator A5026922482 @default.
• W2001632704 creator A5027272944 @default.
• W2001632704 creator A5046820035 @default.
• W2001632704 creator A5049384131 @default.
• W2001632704 creator A5058554441 @default.
• W2001632704 creator A5076096942 @default.
• W2001632704 creator A5076426976 @default.
• W2001632704 creator A5083507260 @default.
• W2001632704 date "2013-10-01" @default.
• W2001632704 modified "2023-09-23" @default.
• W2001632704 title "Development and evaluation of a sandwich ELISA method for the detection of human CD306" @default.
• W2001632704 cites W1889353829 @default.
• W2001632704 cites W1923148706 @default.
• W2001632704 cites W1989653346 @default.
• W2001632704 cites W1994669261 @default.
• W2001632704 cites W1996655452 @default.
• W2001632704 cites W2005790730 @default.
• W2001632704 cites W2006238050 @default.
• W2001632704 cites W2007897798 @default.
• W2001632704 cites W2035822161 @default.
• W2001632704 cites W2037184282 @default.
• W2001632704 cites W2044855636 @default.
• W2001632704 cites W2050105548 @default.
• W2001632704 cites W2076227586 @default.
• W2001632704 cites W2092606926 @default.
• W2001632704 cites W2106928819 @default.
• W2001632704 cites W2118008248 @default.
• W2001632704 cites W2122760156 @default.
• W2001632704 cites W2125310843 @default.
• W2001632704 cites W2125886784 @default.
• W2001632704 cites W2131381643 @default.
• W2001632704 cites W2155893315 @default.
• W2001632704 cites W2162509998 @default.
• W2001632704 cites W4298539079 @default.
• W2001632704 doi "https://doi.org/10.1016/j.jim.2013.07.013" @default.
• W2001632704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23954474" @default.
• W2001632704 hasPublicationYear "2013" @default.
• W2001632704 type Work @default.
• W2001632704 sameAs 2001632704 @default.
• W2001632704 citedByCount "4" @default.
• W2001632704 countsByYear W20016327042016 @default.
• W2001632704 countsByYear W20016327042019 @default.
• W2001632704 countsByYear W20016327042022 @default.
• W2001632704 crossrefType "journal-article" @default.
• W2001632704 hasAuthorship W2001632704A5006088751 @default.
• W2001632704 hasAuthorship W2001632704A5006822602 @default.
• W2001632704 hasAuthorship W2001632704A5026922482 @default.
• W2001632704 hasAuthorship W2001632704A5027272944 @default.
• W2001632704 hasAuthorship W2001632704A5046820035 @default.
• W2001632704 hasAuthorship W2001632704A5049384131 @default.
• W2001632704 hasAuthorship W2001632704A5058554441 @default.
• W2001632704 hasAuthorship W2001632704A5076096942 @default.
• W2001632704 hasAuthorship W2001632704A5076426976 @default.
• W2001632704 hasAuthorship W2001632704A5083507260 @default.
• W2001632704 hasConcept C104317684 @default.
• W2001632704 hasConcept C123894998 @default.
• W2001632704 hasConcept C134018914 @default.
• W2001632704 hasConcept C137061746 @default.
• W2001632704 hasConcept C153911025 @default.
• W2001632704 hasConcept C159654299 @default.
• W2001632704 hasConcept C187882448 @default.
• W2001632704 hasConcept C202751555 @default.
• W2001632704 hasConcept C203014093 @default.
• W2001632704 hasConcept C2780026642 @default.
• W2001632704 hasConcept C40767141 @default.
• W2001632704 hasConcept C542903549 @default.
• W2001632704 hasConcept C55493867 @default.
• W2001632704 hasConcept C71924100 @default.
• W2001632704 hasConcept C86803240 @default.
• W2001632704 hasConceptScore W2001632704C104317684 @default.
• W2001632704 hasConceptScore W2001632704C123894998 @default.
• W2001632704 hasConceptScore W2001632704C134018914 @default.
• W2001632704 hasConceptScore W2001632704C137061746 @default.
• W2001632704 hasConceptScore W2001632704C153911025 @default.
• W2001632704 hasConceptScore W2001632704C159654299 @default.
• W2001632704 hasConceptScore W2001632704C187882448 @default.
• W2001632704 hasConceptScore W2001632704C202751555 @default.
• W2001632704 hasConceptScore W2001632704C203014093 @default.
• W2001632704 hasConceptScore W2001632704C2780026642 @default.
• W2001632704 hasConceptScore W2001632704C40767141 @default.
• W2001632704 hasConceptScore W2001632704C542903549 @default.
• W2001632704 hasConceptScore W2001632704C55493867 @default.
• W2001632704 hasConceptScore W2001632704C71924100 @default.
• W2001632704 hasConceptScore W2001632704C86803240 @default.
• W2001632704 hasIssue "1-2" @default.
• W2001632704 hasLocation W20016327041 @default.
• W2001632704 hasLocation W20016327042 @default.
• W2001632704 hasOpenAccess W2001632704 @default.
• W2001632704 hasPrimaryLocation W20016327041 @default.
• W2001632704 hasRelatedWork W2007269451 @default.
• W2001632704 hasRelatedWork W2073365177 @default.
• W2001632704 hasRelatedWork W2351629474 @default.
• W2001632704 hasRelatedWork W2365344888 @default.
• W2001632704 hasRelatedWork W2367085638 @default.

• next