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• W2001635982 abstract "The present study tested whether aging sensitizes hippocampal microglia to a pro-inflammatory challenge ex vivo. Hippocampal microglia from 3 and 24mo old male F344×BN F1 rats were exposed to LPS (0, 0.1, 1, 10 and 100 ng/ml) ex vivo. 2 h post-LPS challenge, gene expression of microglial activation markers and cytokines were assessed. 24mo old animals exhibited a potentiated pro-inflammatory cytokine (IL-1β and IL-6) response to LPS and increased levels of CD11b, Iba-1 and MHCII irrespective of LPS treatment. The present results demonstrate that aging sensitizes hippocampal microglia to pro-inflammatory challenges." @default.
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• W2001635982 date "2010-09-14" @default.
• W2001635982 modified "2023-10-18" @default.
• W2001635982 title "Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo" @default.
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• W2001635982 doi "https://doi.org/10.1016/j.jneuroim.2010.05.022" @default.
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