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- W2001640596 abstract "The aim of this study was to evaluate the activity of fluconazole against 32 clinical strains of fluconazole-resistant Candida albicans , and C. albicans ATCC 10231 reference strain, after their exposure to sublethal concentrations of tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested fluconazole-resistant C. albicans strains TTO and terpinen-4-ol minimal inhibitory concentrations (MICs) were low, ranging from 0.06% to 0.5%. The 24-hour exposure of fluconazole-resistant C. albicans strains to fluconazole with sublethal dose of TTO enhanced fluconazole activity against these strains. Overall, 62.5% of isolates were classified as susceptible, 25.0% exhibited intermediate susceptibility, and 12.5% were resistant. For all of the tested clinical strains the fluconazole MIC decreased from an average of 244.0 μ g/mL to an average of 38.46 μ g/mL, and the fluconazole minimal fungicidal concentrations (MFC) decreased from an average of 254.67 μ g/mL to an average of 66.62 μ g/mL. Terpinen-4-ol was found to be more active than TTO, and strongly enhanced fluconazole activity against fluconazole-resistant C. albicans strains. The results of this study demonstrate that combining natural substances such as TTO and conventional drug such as fluconazole, may help treat difficult yeast infections." @default.
- W2001640596 created "2016-06-24" @default.
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- W2001640596 date "2015-01-01" @default.
- W2001640596 modified "2023-10-11" @default.
- W2001640596 title "The Influence of Tea Tree Oil (<i>Melaleuca alternifolia</i>) on Fluconazole Activity against Fluconazole-Resistant<i>Candida albicans</i>Strains" @default.
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- W2001640596 doi "https://doi.org/10.1155/2015/590470" @default.
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