FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001640894> ?p ?o ?g. }

• W2001640894 endingPage "3106" @default.
• W2001640894 startingPage "3095" @default.
• W2001640894 abstract "Diadenosine 5‘,5‘ ‘‘-P1,P4-tetraphosphate (Ap4A) is a dinucleoside polyphosphate found ubiquitously in eukaryotic and prokaryotic cells. Despite Ap4A being universal, its functions have proved to be difficult to define, although they appear to have a strong presence during cellular stress. Here we report on our investigations into the nature and properties of putative Ap4A interactions with Escherichia coli molecular chaperone GroEL and cAMP receptor protein (CRP). We confirm previous literature observations that GroEL is an Ap4A binding protein and go on to prove that binding of Ap4A to GroEL involves a set of binding sites (one per monomer) distinct from the well-known GroEL ATP/ADP sites. Binding of Ap4A to GroEL appears to enhance ATPase rates at higher temperatures, encourages the release of bound ADP, and may promote substrate protein release through differential destabilization of the substrate protein−GroEL complex. We suggest that such effects should result in enhanced GroEL/GroES chaperoning activities that could be a primary reason for the improved yields of the refolded substrate protein observed during GroEL/GroES-assisted folding and refolding at ≥30 °C in the presence of Ap4A. In contrast, we were unable to obtain any data to support a direct role for Ap4A interactions with CRP." @default.
• W2001640894 created "2016-06-24" @default.
• W2001640894 creator A5013581897 @default.
• W2001640894 creator A5029017223 @default.
• W2001640894 creator A5031922498 @default.
• W2001640894 creator A5059845506 @default.
• W2001640894 creator A5071466799 @default.
• W2001640894 date "2006-02-11" @default.
• W2001640894 modified "2023-10-17" @default.
• W2001640894 title "Investigation into the Interactions between Diadenosine 5‘,5‘ ‘‘-<i>P</i>¹,<i>P</i>⁴-Tetraphosphate and Two Proteins: Molecular Chaperone GroEL and cAMP Receptor Protein" @default.
• W2001640894 cites W141737879 @default.
• W2001640894 cites W1482341644 @default.
• W2001640894 cites W1978704032 @default.
• W2001640894 cites W1981191309 @default.
• W2001640894 cites W1981582437 @default.
• W2001640894 cites W1985114988 @default.
• W2001640894 cites W1993224587 @default.
• W2001640894 cites W1994967468 @default.
• W2001640894 cites W2000040972 @default.
• W2001640894 cites W2007894261 @default.
• W2001640894 cites W2010780934 @default.
• W2001640894 cites W2016901528 @default.
• W2001640894 cites W2028717691 @default.
• W2001640894 cites W2038108884 @default.
• W2001640894 cites W2044597760 @default.
• W2001640894 cites W2054721713 @default.
• W2001640894 cites W2062002135 @default.
• W2001640894 cites W2065662230 @default.
• W2001640894 cites W2080688660 @default.
• W2001640894 cites W2087515013 @default.
• W2001640894 cites W2111950681 @default.
• W2001640894 cites W2150301908 @default.
• W2001640894 cites W2160675155 @default.
• W2001640894 cites W2166457914 @default.
• W2001640894 cites W2167023571 @default.
• W2001640894 cites W2323537008 @default.
• W2001640894 cites W2412434497 @default.
• W2001640894 cites W4249758294 @default.
• W2001640894 cites W4313333846 @default.
• W2001640894 doi "https://doi.org/10.1021/bi052529k" @default.
• W2001640894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16503665" @default.
• W2001640894 hasPublicationYear "2006" @default.
• W2001640894 type Work @default.
• W2001640894 sameAs 2001640894 @default.
• W2001640894 citedByCount "14" @default.
• W2001640894 countsByYear W20016408942012 @default.
• W2001640894 countsByYear W20016408942013 @default.
• W2001640894 countsByYear W20016408942014 @default.
• W2001640894 countsByYear W20016408942015 @default.
• W2001640894 countsByYear W20016408942016 @default.
• W2001640894 countsByYear W20016408942020 @default.
• W2001640894 crossrefType "journal-article" @default.
• W2001640894 hasAuthorship W2001640894A5013581897 @default.
• W2001640894 hasAuthorship W2001640894A5029017223 @default.
• W2001640894 hasAuthorship W2001640894A5031922498 @default.
• W2001640894 hasAuthorship W2001640894A5059845506 @default.
• W2001640894 hasAuthorship W2001640894A5071466799 @default.
• W2001640894 hasConcept C104317684 @default.
• W2001640894 hasConcept C107824862 @default.
• W2001640894 hasConcept C12554922 @default.
• W2001640894 hasConcept C142724271 @default.
• W2001640894 hasConcept C185592680 @default.
• W2001640894 hasConcept C204328495 @default.
• W2001640894 hasConcept C2775962898 @default.
• W2001640894 hasConcept C46522908 @default.
• W2001640894 hasConcept C547475151 @default.
• W2001640894 hasConcept C55493867 @default.
• W2001640894 hasConcept C71924100 @default.
• W2001640894 hasConcept C85755625 @default.
• W2001640894 hasConcept C86803240 @default.
• W2001640894 hasConcept C87190427 @default.
• W2001640894 hasConcept C98924942 @default.
• W2001640894 hasConceptScore W2001640894C104317684 @default.
• W2001640894 hasConceptScore W2001640894C107824862 @default.
• W2001640894 hasConceptScore W2001640894C12554922 @default.
• W2001640894 hasConceptScore W2001640894C142724271 @default.
• W2001640894 hasConceptScore W2001640894C185592680 @default.
• W2001640894 hasConceptScore W2001640894C204328495 @default.
• W2001640894 hasConceptScore W2001640894C2775962898 @default.
• W2001640894 hasConceptScore W2001640894C46522908 @default.
• W2001640894 hasConceptScore W2001640894C547475151 @default.
• W2001640894 hasConceptScore W2001640894C55493867 @default.
• W2001640894 hasConceptScore W2001640894C71924100 @default.
• W2001640894 hasConceptScore W2001640894C85755625 @default.
• W2001640894 hasConceptScore W2001640894C86803240 @default.
• W2001640894 hasConceptScore W2001640894C87190427 @default.
• W2001640894 hasConceptScore W2001640894C98924942 @default.
• W2001640894 hasIssue "9" @default.
• W2001640894 hasLocation W20016408941 @default.
• W2001640894 hasLocation W20016408942 @default.
• W2001640894 hasOpenAccess W2001640894 @default.
• W2001640894 hasPrimaryLocation W20016408941 @default.
• W2001640894 hasRelatedWork W1193834291 @default.
• W2001640894 hasRelatedWork W1552392580 @default.
• W2001640894 hasRelatedWork W1989967308 @default.
• W2001640894 hasRelatedWork W2016698833 @default.
• W2001640894 hasRelatedWork W2018096567 @default.
• W2001640894 hasRelatedWork W2035292024 @default.

• next