Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001653062> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2001653062 endingPage "1550" @default.
- W2001653062 startingPage "1533" @default.
- W2001653062 abstract "—The accumulation by synaptosomal fractions from rat central nervous system tissue of transmitter candidate amino acids and non-candidate amino acids was studied with respect to ionic requirements, metabolic inhibitors, structural analogues, and ontogeny. For l-glutamic and l-aspartic acids in cortex and spinal cord and glycine in spinal cord a stringent sodium requirement for high affinity uptake was demonstrated. Detailed kinetic analysis of the sodium requirement for glutamic acid uptake into cortical synaptosomal fractions suggests that: (1) sodium ion acts both competitively and non-competitively in determining the velocity of high affinity uptake; (2) in the absence of sodium ion only the low affinity uptake can be demonstrated; and (3) inhibition of the Na–K-ATPase enzyme system with ouabain reduces the velocity of uptake to 60% of control values in contrast to alanine whose synaptosomal uptake is less dependent on this enzyme system. No potent inhibitors of l-glutamic acid accumulation were found among several structural analogues or derivatives. The kinetic analysis for glycine accumulation was more complex and suggested allosteric interactions between glycine and sodium ion. Developmental studies revealed GABA and l-glutamic acid to have absolute sodium requirements for cortical synaptosomal accumulation from the 16th gestational day through adulthood, with glycine accumulation showing a decreasing sodium requirement as maturation proceeded over this period. The combined evidence suggests that sodium requirement for high affinity uptake is a characteristic of neuroactive substances and may be used as a screening tool to search for other neurotransmitter candidates." @default.
- W2001653062 created "2016-06-24" @default.
- W2001653062 creator A5015039227 @default.
- W2001653062 creator A5020208893 @default.
- W2001653062 creator A5062220925 @default.
- W2001653062 date "1973-12-01" @default.
- W2001653062 modified "2023-09-26" @default.
- W2001653062 title "AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for l-GLUTAMIC AND l-ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT" @default.
- W2001653062 cites W1510831493 @default.
- W2001653062 cites W1966480571 @default.
- W2001653062 cites W1967532153 @default.
- W2001653062 cites W1970480967 @default.
- W2001653062 cites W1980829665 @default.
- W2001653062 cites W1981604210 @default.
- W2001653062 cites W1984723783 @default.
- W2001653062 cites W1985868885 @default.
- W2001653062 cites W1988534771 @default.
- W2001653062 cites W200284424 @default.
- W2001653062 cites W2006712669 @default.
- W2001653062 cites W2007556848 @default.
- W2001653062 cites W2010496081 @default.
- W2001653062 cites W2017635992 @default.
- W2001653062 cites W2017693171 @default.
- W2001653062 cites W2042483170 @default.
- W2001653062 cites W2046370585 @default.
- W2001653062 cites W2051024351 @default.
- W2001653062 cites W2064739673 @default.
- W2001653062 cites W2064906453 @default.
- W2001653062 cites W2083909102 @default.
- W2001653062 cites W2086874051 @default.
- W2001653062 cites W2093723982 @default.
- W2001653062 cites W2124990645 @default.
- W2001653062 cites W2146855480 @default.
- W2001653062 cites W2150781451 @default.
- W2001653062 cites W2162791087 @default.
- W2001653062 cites W2287727922 @default.
- W2001653062 doi "https://doi.org/10.1111/j.1471-4159.1973.tb06037.x" @default.
- W2001653062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4149183" @default.
- W2001653062 hasPublicationYear "1973" @default.
- W2001653062 type Work @default.
- W2001653062 sameAs 2001653062 @default.
- W2001653062 citedByCount "256" @default.
- W2001653062 countsByYear W20016530622012 @default.
- W2001653062 countsByYear W20016530622013 @default.
- W2001653062 countsByYear W20016530622014 @default.
- W2001653062 countsByYear W20016530622016 @default.
- W2001653062 countsByYear W20016530622017 @default.
- W2001653062 countsByYear W20016530622021 @default.
- W2001653062 crossrefType "journal-article" @default.
- W2001653062 hasAuthorship W2001653062A5015039227 @default.
- W2001653062 hasAuthorship W2001653062A5020208893 @default.
- W2001653062 hasAuthorship W2001653062A5062220925 @default.
- W2001653062 hasConcept C178790620 @default.
- W2001653062 hasConcept C185592680 @default.
- W2001653062 hasConcept C2777756961 @default.
- W2001653062 hasConcept C2778740566 @default.
- W2001653062 hasConcept C2779133857 @default.
- W2001653062 hasConcept C2779856020 @default.
- W2001653062 hasConcept C2781208047 @default.
- W2001653062 hasConcept C515207424 @default.
- W2001653062 hasConcept C537181965 @default.
- W2001653062 hasConcept C55493867 @default.
- W2001653062 hasConceptScore W2001653062C178790620 @default.
- W2001653062 hasConceptScore W2001653062C185592680 @default.
- W2001653062 hasConceptScore W2001653062C2777756961 @default.
- W2001653062 hasConceptScore W2001653062C2778740566 @default.
- W2001653062 hasConceptScore W2001653062C2779133857 @default.
- W2001653062 hasConceptScore W2001653062C2779856020 @default.
- W2001653062 hasConceptScore W2001653062C2781208047 @default.
- W2001653062 hasConceptScore W2001653062C515207424 @default.
- W2001653062 hasConceptScore W2001653062C537181965 @default.
- W2001653062 hasConceptScore W2001653062C55493867 @default.
- W2001653062 hasIssue "6" @default.
- W2001653062 hasLocation W20016530621 @default.
- W2001653062 hasLocation W20016530622 @default.
- W2001653062 hasOpenAccess W2001653062 @default.
- W2001653062 hasPrimaryLocation W20016530621 @default.
- W2001653062 hasRelatedWork W106428672 @default.
- W2001653062 hasRelatedWork W1999283450 @default.
- W2001653062 hasRelatedWork W2044427462 @default.
- W2001653062 hasRelatedWork W2046782971 @default.
- W2001653062 hasRelatedWork W2070456456 @default.
- W2001653062 hasRelatedWork W2073721838 @default.
- W2001653062 hasRelatedWork W2094611941 @default.
- W2001653062 hasRelatedWork W2143260285 @default.
- W2001653062 hasRelatedWork W2309489207 @default.
- W2001653062 hasRelatedWork W2355079202 @default.
- W2001653062 hasVolume "21" @default.
- W2001653062 isParatext "false" @default.
- W2001653062 isRetracted "false" @default.
- W2001653062 magId "2001653062" @default.
- W2001653062 workType "article" @default.