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• W2001657042 abstract "Sequence variations with biologic effect in ALS have been identified in the gene for vascular endothelial growth factor (VEGF). The gene for a related protein, angiogenin, lies on chromosome 14q11.2. Analysis of the angiogenin (<i>ANG</i>) gene in the authors’ population has demonstrated a significant allelic association with the rs11701 single nucleotide polymorphism (SNP) and identified a novel mutation in two individuals with sporadic ALS that potentially inhibits angiogenin function. These observations propose a candidate region for ALS on chromosome 14q11.2 and suggest that other genes with similar function to VEGF may be important in the pathogenesis of ALS." @default.
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• W2001657042 date "2004-11-22" @default.
• W2001657042 modified "2023-09-25" @default.
• W2001657042 title "A novel candidate region for ALS on chromosome 14q11.2" @default.
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• W2001657042 doi "https://doi.org/10.1212/01.wnl.0000144344.39103.f6" @default.
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