Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001663872> ?p ?o ?g. }
- W2001663872 abstract "Cyclic nucleotide phosphodiesterases (PDE) 3 and 5 regulate cAMP and cGMP signalling in cardiac and smooth muscle myocytes. Important advances in the understanding of the roles of these enzymes have recently been made. PDE3 inhibitors have inotropic and vasodilatory properties, and although they acutely improve haemodynamics in patients with heart failure, they do not improve long-term morbidity and mortality. Although combination therapy with beta-adrenergic receptor antagonists or selective inhibition of specific PDE3 isoforms might result in a more favourable long-term outcome, more clinical data are needed to test this proposition. The role of PDE5 inhibitors in the treatment of cardiac disease is evolving. PDE5 inhibitors cause pulmonary and systemic vasodilation. How these drugs will compare with other vasodilators in terms of long-term outcomes in patients with heart failure is unknown. Recent studies also suggest that PDE5 inhibitors may have antihypertropic effects, exerted through increased myocardial cGMP signalling, that could be of additional benefit in patients with heart failure." @default.
- W2001663872 created "2016-06-24" @default.
- W2001663872 creator A5059653014 @default.
- W2001663872 creator A5062027051 @default.
- W2001663872 date "2006-06-21" @default.
- W2001663872 modified "2023-09-24" @default.
- W2001663872 title "Inhibitors of cyclic nucleotide phosphodiesterase 3 and 5 as therapeutic agents in heart failure" @default.
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