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• W2001665547 startingPage "e28359" @default.
• W2001665547 abstract "When mammalian spermatozoa become capacitated they acquire, among other activities, chemotactic responsiveness and the ability to exhibit occasional events of hyperactivated motility—a vigorous motility type with large amplitudes of head displacement. Although a number of roles have been proposed for this type of motility, its function is still obscure. Here we provide evidence suggesting that hyperactivation is part of the chemotactic response. By analyzing tracks of spermatozoa swimming in a spatial chemoattractant gradient we demonstrate that, in such a gradient, the level of hyperactivation events is significantly lower than in proper controls. This suggests that upon sensing an increase in the chemoattractant concentration capacitated cells repress their hyperactivation events and thus maintain their course of swimming toward the chemoattractant. Furthermore, in response to a temporal concentration jump achieved by photorelease of the chemoattractant progesterone from its caged form, the responsive cells exhibited a delayed turn, often accompanied by hyperactivation events or an even more intense response in the form of flagellar arrest. This study suggests that the function of hyperactivation is to cause a rather sharp turn during the chemotactic response of capacitated cells so as to assist them to reorient according to the chemoattractant gradient. On the basis of these results a model for the behavior of spermatozoa responding to a spatial chemoattractant gradient is proposed." @default.
• W2001665547 created "2016-06-24" @default.
• W2001665547 creator A5024496164 @default.
• W2001665547 creator A5063601237 @default.
• W2001665547 date "2011-12-07" @default.
• W2001665547 modified "2023-10-16" @default.
• W2001665547 title "Behavioral Mechanism during Human Sperm Chemotaxis: Involvement of Hyperactivation" @default.
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• W2001665547 doi "https://doi.org/10.1371/journal.pone.0028359" @default.
• W2001665547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3233563" @default.
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• W2001665547 hasPublicationYear "2011" @default.
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