FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001675114> ?p ?o ?g. }

• W2001675114 abstract "Tacrolimus, a macrolide immunosuppressant, is used topically for the treatment of cutaneous manifestations of graft-versus-host disease (GVHD) for rapid, symptomatic relief of pruritus and erythema. Despite the manufacturer's product information reporting minimal systemic effects of topical tacrolimus, this has not been evaluated in patients with cutaneous GVHD and with occlusive dressings. We describe two patients with cutaneous GVHD who developed toxic tacrolimus levels after receiving several applications of tacrolimus ointment along with occlusive dressings to enhance skin effectiveness. The first patient was a 62-year-old woman with a history of acute myelogenous leukemia (AML) who underwent allogeneic bone marrow transplantation and developed chronic GVHD involving 70% of her body surface area. Her GVHD treatment plan consisted of oral corticosteroids, oral tacrolimus, topical corticosteroids, topical tacrolimus 0.1% ointment twice/day, emollient creams, intravenous rituximab, and photopheresis. The patient's tacrolimus trough levels rose rapidly over the course of 6 days from less than 2 ng/ml to 23 ng/ml, despite oral tacrolimus dosage adjustments. The second patient was a 25-year-old man who developed severe, chronic skin GVHD after undergoing allogeneic sibling bone marrow transplantation for AML. In addition to intravenous corticosteroids, corticosteroid creams, and oral tacrolimus, the patient also received topical tacrolimus twice/day with occlusive dressings. Over the course of 2 days, his tacrolimus trough levels increased from 7.10 ng/ml to 22.10 ng/ml. Although improvement was noted in both patients' skin GVHD with application of the occlusive dressings, the practice was discontinued due to increased and erratic systemic tacrolimus absorption. These case reports suggest that substantial use of topical tacrolimus with occlusive dressings in patients with cutaneous GVHD may contribute to increased systemic absorption resulting in toxic tacrolimus levels. Based on the findings from our two patients as well as published case reports, systemic absorption appears to increase with greater skin permeability, skin barrier dysfunction, amount of body surface area applied, and use of occlusive dressings. When one or more of these factors are present, it may be prudent to monitor tacrolimus levels." @default.
• W2001675114 created "2016-06-24" @default.
• W2001675114 creator A5001550111 @default.
• W2001675114 creator A5063351800 @default.
• W2001675114 creator A5091193130 @default.
• W2001675114 date "2014-04-03" @default.
• W2001675114 modified "2023-10-16" @default.
• W2001675114 title "Toxic Tacrolimus Levels After Application of Topical Tacrolimus and Use of Occlusive Dressings in Two Bone Marrow Transplant Recipients with Cutaneous Graft-versus-Host Disease" @default.
• W2001675114 cites W1968086046 @default.
• W2001675114 cites W1984971284 @default.
• W2001675114 cites W1999410809 @default.
• W2001675114 cites W2063480361 @default.
• W2001675114 cites W2119612227 @default.
• W2001675114 cites W2140035829 @default.
• W2001675114 cites W4251333130 @default.
• W2001675114 doi "https://doi.org/10.1002/phar.1418" @default.
• W2001675114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24700567" @default.
• W2001675114 hasPublicationYear "2014" @default.
• W2001675114 type Work @default.
• W2001675114 sameAs 2001675114 @default.
• W2001675114 citedByCount "21" @default.
• W2001675114 countsByYear W20016751142014 @default.
• W2001675114 countsByYear W20016751142015 @default.
• W2001675114 countsByYear W20016751142016 @default.
• W2001675114 countsByYear W20016751142017 @default.
• W2001675114 countsByYear W20016751142018 @default.
• W2001675114 countsByYear W20016751142019 @default.
• W2001675114 countsByYear W20016751142020 @default.
• W2001675114 countsByYear W20016751142021 @default.
• W2001675114 countsByYear W20016751142022 @default.
• W2001675114 countsByYear W20016751142023 @default.
• W2001675114 crossrefType "journal-article" @default.
• W2001675114 hasAuthorship W2001675114A5001550111 @default.
• W2001675114 hasAuthorship W2001675114A5063351800 @default.
• W2001675114 hasAuthorship W2001675114A5091193130 @default.
• W2001675114 hasConcept C141071460 @default.
• W2001675114 hasConcept C16005928 @default.
• W2001675114 hasConcept C2779121184 @default.
• W2001675114 hasConcept C2779972918 @default.
• W2001675114 hasConcept C2909675724 @default.
• W2001675114 hasConcept C2911091166 @default.
• W2001675114 hasConcept C71924100 @default.
• W2001675114 hasConcept C90924648 @default.
• W2001675114 hasConceptScore W2001675114C141071460 @default.
• W2001675114 hasConceptScore W2001675114C16005928 @default.
• W2001675114 hasConceptScore W2001675114C2779121184 @default.
• W2001675114 hasConceptScore W2001675114C2779972918 @default.
• W2001675114 hasConceptScore W2001675114C2909675724 @default.
• W2001675114 hasConceptScore W2001675114C2911091166 @default.
• W2001675114 hasConceptScore W2001675114C71924100 @default.
• W2001675114 hasConceptScore W2001675114C90924648 @default.
• W2001675114 hasIssue "6" @default.
• W2001675114 hasLocation W20016751141 @default.
• W2001675114 hasLocation W20016751142 @default.
• W2001675114 hasOpenAccess W2001675114 @default.
• W2001675114 hasPrimaryLocation W20016751141 @default.
• W2001675114 hasRelatedWork W1967987848 @default.
• W2001675114 hasRelatedWork W2003921494 @default.
• W2001675114 hasRelatedWork W2049390878 @default.
• W2001675114 hasRelatedWork W2095882963 @default.
• W2001675114 hasRelatedWork W2111975076 @default.
• W2001675114 hasRelatedWork W2384248322 @default.
• W2001675114 hasRelatedWork W3150855330 @default.
• W2001675114 hasRelatedWork W3207196874 @default.
• W2001675114 hasRelatedWork W4200557508 @default.
• W2001675114 hasRelatedWork W4236551239 @default.
• W2001675114 hasVolume "34" @default.
• W2001675114 isParatext "false" @default.
• W2001675114 isRetracted "false" @default.
• W2001675114 magId "2001675114" @default.
• W2001675114 workType "article" @default.