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- W2001678296 abstract "Gonadotrophic hormones appear to influence the preferred pathways for intratesticular androgen biosynthesis. Individuals with low levels of gonadotrophin in the peripheral circulation, as e. g. prepubertal boys and a hypophysectomized adult male, have previously been shown to metabolize [ 3 H]progesterone in vitro mainly to 20α‐dihydroprogesterone (20α‐DH‐P) and less to 17α‐hydroxyprogesterone (17α‐OH‐P), i. e. an “immature metabolic pattern” (Berg et al. 1976; Kjessler & Berg 1976b). With physiologically increasing amounts of circulating gonadotrophins the preferred metabolic pathway in vitro shifts in favour of 17α‐OH‐P, i. e. a “mature metabolic pattern”. Such an alteration in the preferred in vitro metabolic pattern of [ 3 H]progesterone has also been obtained by exogenous administration of gonadotrophins to a 47, XYY‐male with an initially immature metabolic pattern (Berg & Kjessler 1976). We have sequentially analysed the metabolism of [ 3 H]progesterone in vitro in testicular incubates derived from a chromosomally normal male before and after 16 weeks of substitution therapy with gonadotrophic hormones. The patient originally displayed an “immature” pattern of progesterone metabolites, i. e. the ratio 20α‐DH‐P/17é‐OH‐P was 3.04. After treatment with human menopausal gonadotrophins and hCG, the metabolic activity in total had increased, and the ratio 20é‐DH‐P/17é‐OH‐P had switched to 0.39. These results confirm and extend the concept that gonadotrophic hormones may have a regulatory function on androgen biosynthesis by stimulating the oxidative metabolic pathway from progesterone to biologically active androgens via 17α‐hydroxyprogesterone." @default.
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- W2001678296 date "1978-12-01" @default.
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- W2001678296 title "Effect of Long Term Treatment with Gonadotrophic Hormones on In Vitro Metabolism of [3H]Progesterone in Human Testicular Tissue" @default.
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- W2001678296 doi "https://doi.org/10.1111/j.1365-2605.1978.tb00576.x" @default.
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